Dietary folate intake and fecundability in two preconception cohorts

Abstract STUDY QUESTION To what extent is dietary folate intake and total folate intake (dietary and supplemental intakes) associated with fecundability, the per cycle probability of conception? SUMMARY ANSWER Preconception dietary folate intake was positively associated with fecundability in a mono...

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Published in:Human reproduction (Oxford) 2022-04, Vol.37 (4), p.828-837
Main Authors: Cueto, Heidi T, Jacobsen, Bjarke H, Laursen, Anne Sofie Dam, Riis, Anders H, Hatch, Elizabeth E, Wise, Lauren A, Trolle, Ellen, Sørensen, Henrik Toft, Rothman, Kenneth J, Wesselink, Amelia K, Willis, Sydney, Johannesen, Benjamin R, Mikkelsen, Ellen M
Format: Article
Language:English
Subjects:
Child
Eating
Female
Fertility
Fertilization
Folic Acid
Humans
Original
Pregnancy
Prospective Studies
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Summary:Abstract STUDY QUESTION To what extent is dietary folate intake and total folate intake (dietary and supplemental intakes) associated with fecundability, the per cycle probability of conception? SUMMARY ANSWER Preconception dietary folate intake was positively associated with fecundability in a monotonic pattern. WHAT IS KNOWN ALREADY Supplemental folic acid has been associated with improved fertility, but little is known about the relation between dietary folate and fecundability. STUDY DESIGN, SIZE, DURATION A prospective cohort study including 9559 women trying to conceive without fertility treatment and enrolled in the period 2013-2020. PARTICIPANTS/MATERIALS, SETTING, METHODS We used data from two internet-based prospective cohort studies of pregnancy planners from Denmark, where folic acid fortification is not performed (SnartForældre.dk (SF); n = 3755) and North America, where the food supply is fortified with folic acid (Pregnancy Study Online (PRESTO); n = 5804). Women contributed menstrual cycles at risk until they reported conception or experienced a censoring event. We used proportional probabilities regression models to compute fecundability ratios (FRs) and 95% CI, adjusting for potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE Compared with a dietary folate intake ≥400 µg/day, the adjusted FRs for women in SF were 0.92 (95% CI: 0.85–0.99) for intake 250–399 µg/day, and 0.80 (95% CI: 0.68–0.94) for intake of
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deac002