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Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides
The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp 2 -Csp 3 bond, which p...
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Published in: | RSC advances 2022-01, Vol.12 (6), p.3569-3572 |
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container_title | RSC advances |
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creator | Gao, Nanxing Li, Yanshun Teng, Dawei |
description | The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp
2
-Csp
3
bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
The structure of primary alkylated arenes play an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed. |
doi_str_mv | 10.1039/d2ra00010e |
format | article |
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2
-Csp
3
bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
The structure of primary alkylated arenes play an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra00010e</identifier><identifier>PMID: 35425390</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aldehydes ; Alkylation ; Aromatic compounds ; Bromides ; Chemistry ; Coupling (molecular) ; Functional groups ; Ketones ; Natural products ; Nickel</subject><ispartof>RSC advances, 2022-01, Vol.12 (6), p.3569-3572</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2022</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-64c7fe5103ee9963ad3ee5d5850914aa65cba82da5386e248d16300371246e3b3</citedby><cites>FETCH-LOGICAL-c358t-64c7fe5103ee9963ad3ee5d5850914aa65cba82da5386e248d16300371246e3b3</cites><orcidid>0000-0001-8904-6491 ; 0000-0003-1629-3787 ; 0000-0002-9051-6013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35425390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Nanxing</creatorcontrib><creatorcontrib>Li, Yanshun</creatorcontrib><creatorcontrib>Teng, Dawei</creatorcontrib><title>Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp
2
-Csp
3
bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
The structure of primary alkylated arenes play an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed.</description><subject>Aldehydes</subject><subject>Alkylation</subject><subject>Aromatic compounds</subject><subject>Bromides</subject><subject>Chemistry</subject><subject>Coupling (molecular)</subject><subject>Functional groups</subject><subject>Ketones</subject><subject>Natural products</subject><subject>Nickel</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLAzEUhYMoKrUb98qAGxFG8-7MRihaH1AURMFdSJNbHU0nNZkR_PemD2t1lUvOx-HcexDaJ_iUYFaeWRo0xphg2EC7FHOZUyzLzbV5B3VjfEsMloJQSbbRDhOcClbiXfR8V5l3cLnRjXZfEWxmgo8xBwemCX76WjnIjG-nrqpfMj_OdPhy2Sj4SWUhZrq22TRUk_Sbafe-Ju2hrbF2EbrLt4OergaPFzf58P769qI_zA0TRZNLbnpjEGkVgLKUTNs0CCsKgUvCtZbCjHRBrRaskEB5YYlkGLMeoVwCG7EOOl_4TtvRBKyBugnaqWUo5XWl_ip19ape_Kcqyl5JpUwGx0uD4D9aiI2aVNGAc7oG30ZF09VkIXiPJ_ToH_rm21Cn9RJFGZeC4xl1sqDmlwwwXoUhWM06U5f0oT_vbJDgw_X4K_SnoQQcLIAQzUr9LZ19A_ysm98</recordid><startdate>20220124</startdate><enddate>20220124</enddate><creator>Gao, Nanxing</creator><creator>Li, Yanshun</creator><creator>Teng, Dawei</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8904-6491</orcidid><orcidid>https://orcid.org/0000-0003-1629-3787</orcidid><orcidid>https://orcid.org/0000-0002-9051-6013</orcidid></search><sort><creationdate>20220124</creationdate><title>Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides</title><author>Gao, Nanxing ; Li, Yanshun ; Teng, Dawei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-64c7fe5103ee9963ad3ee5d5850914aa65cba82da5386e248d16300371246e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aldehydes</topic><topic>Alkylation</topic><topic>Aromatic compounds</topic><topic>Bromides</topic><topic>Chemistry</topic><topic>Coupling (molecular)</topic><topic>Functional groups</topic><topic>Ketones</topic><topic>Natural products</topic><topic>Nickel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Nanxing</creatorcontrib><creatorcontrib>Li, Yanshun</creatorcontrib><creatorcontrib>Teng, Dawei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Nanxing</au><au>Li, Yanshun</au><au>Teng, Dawei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-01-24</date><risdate>2022</risdate><volume>12</volume><issue>6</issue><spage>3569</spage><epage>3572</epage><pages>3569-3572</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp
2
-Csp
3
bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
The structure of primary alkylated arenes play an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35425390</pmid><doi>10.1039/d2ra00010e</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-8904-6491</orcidid><orcidid>https://orcid.org/0000-0003-1629-3787</orcidid><orcidid>https://orcid.org/0000-0002-9051-6013</orcidid><oa>free_for_read</oa></addata></record> |
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source | PubMed Central |
subjects | Aldehydes Alkylation Aromatic compounds Bromides Chemistry Coupling (molecular) Functional groups Ketones Natural products Nickel |
title | Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides |
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