Vitamin D is Positively Associated with Bone Mineral Density Muscle Mass and Negatively with Insulin Resistance in Senile Diabetes Mellitus

• Published in: Disease markers 2022, Vol.2022, p.9231408-5
• Main Authors: Gao, Yan, Chen, Zhaoyu, Ma, Zijian
• Format: Article
• Language: English
• Subjects: Blood Glucose - analysis; Body mass index; Bone Density; Bone mass; Bone mineral density; Calciferol; Cardiovascular disease; Correlation analysis; Data analysis; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Femur; Fractures; Glucose; Humans; Insulin; Insulin resistance; Insulin Resistance - physiology; Limbs; Muscle strength; Muscles; Older people; Osteoporosis; Patients; Phosphorus; Quality of life; Sarcopenia; Vitamin D; Vitamin D Deficiency - complications; Vitamin deficiency; Vitamins
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2022/9231408

Objective. To explore the correlations between vitamin D level and bone mineral density (BMD), insulin resistance (HOMA-IR), and muscle mass in patients with senile type 2 diabetes mellitus (T2DM). Methods. Totally, 80 patients with senile T2DM admitted to China-Japan Friendship Hospital from Jan 2020 to Oct 2021 were enrolled and assigned to the 25 (OH)D-deficiency group (n=35) or 25(OH)D-normal group (n=45) according to serum 25(OH)D level. BMD and HOMA-IR in the femur neck and muscle masses of upper and lower limbs were compared between the two groups, and Pearson’s correlation analysis was performed to determine the relations between 25(OH)D and BMD, HOMA-IR, and muscle masses of upper and lower limbs. Results. No notable difference was found between the two groups in general data including age, gender, diabetes duration, BMI, HBA 1c, and fasting insulin (all P>0.05). Compared with the 25(OH)D-normal group, the 25 (OH)D-deficiency group showed a notably lower BMD in the femur neck, notably lower muscle masses of upper and lower limbs, and a notably higher HOMA-IR level (all P