SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021)

The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments. While early stages may obtain benefit of local resections without any additional therapies, locally advanced rectal cancer becomes a challenge d...

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Bibliographic Details
Published in:Clinical & translational oncology 2022-04, Vol.24 (4), p.646-657
Main Authors: Capdevila, Jaume, Gómez, Ma Auxiliadora, Guillot, Mónica, Páez, David, Pericay, Carles, Safont, Maria José, Tarazona, Noelia, Vera, Ruth, Vidal, Joana, Sastre, Javier
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemoradiotherapy - methods
Clinical Guides in Oncology
Humans
Medicine
Medicine & Public Health
Neoadjuvant Therapy - methods
Neoplasm Staging
Neoplasms, Second Primary
Oncology
Rectal Neoplasms - pathology
Rectum - surgery
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Summary:The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments. While early stages may obtain benefit of local resections without any additional therapies, locally advanced rectal cancer becomes a challenge defining the better sequential strategy of surgery, radiotherapy and chemotherapy. The latest results of international phase III studies have positioned the total neoadjuvant therapy as a potential new standard of care in high risk rectal cancers, however, the best schedule is still not well defined.
ISSN:1699-3055
1699-048X
1699-3055
DOI:10.1007/s12094-022-02816-9