Bacterial Polyglucuronic Acid/Alginate/Carbon Nanofibers Hydrogel Nanocomposite as a Potential Scaffold for Bone Tissue Engineering

3D nanocomposite scaffolds have attracted significant attention in bone tissue engineering applications. In the current study, we fabricated a 3D nanocomposite scaffold based on a bacterial polyglucuronic acid (PGU) and sodium alginate (Alg) composite with carbon nanofibers (CNFs) as the bone tissue...

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Bibliographic Details
Published in:Materials 2022-03, Vol.15 (7), p.2494
Main Authors: Dibazar, Zahra Ebrahimvand, Mohammadpour, Mahnaz, Samadian, Hadi, Zare, Soheila, Azizi, Mehdi, Hamidi, Masoud, Elboutachfaiti, Redouan, Petit, Emmanuel, Delattre, Cédric
Format: Article
Language:English
Subjects:
Acids
Aluminum
Bacteria
Biocompatibility
Biomedical materials
Bones
Calcium chloride
Carbon fibers
Composite materials
Heat treatment
Hydrogels
Life Sciences
Morphology
Nanocomposites
Nanofibers
Nanomaterials
Polyacrylonitrile
Polymers
Porosity
Scaffolds
Sodium alginate
Tissue engineering
Water absorption
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Summary:3D nanocomposite scaffolds have attracted significant attention in bone tissue engineering applications. In the current study, we fabricated a 3D nanocomposite scaffold based on a bacterial polyglucuronic acid (PGU) and sodium alginate (Alg) composite with carbon nanofibers (CNFs) as the bone tissue engineering scaffold. The CNFs were obtained from electrospun polyacrylonitrile nanofibers through heat treatment. The fabricated CNFs were incorporated into a PGU/Alg polymeric solution, which was physically cross-linked using CaCl solution. The fabricated nanocomposites were characterized to evaluate the internal structure, porosity, swelling kinetics, hemocompatibility, and cytocompatibility. The characterizations indicated that the nanocomposites have a porous structure with interconnected pores architecture, proper water absorption, and retention characteristics. The in vitro studies revealed that the nanocomposites were hemocompatible with negligible hemolysis induction. The cell viability assessment showed that the nanocomposites were biocompatible and supported bone cell growth. These results indicated that the fabricated bacterial PGU/Alg/CNFs hydrogel nanocomposite exhibited appropriate properties and can be considered a new biomaterial for bone tissue engineering scaffolds.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15072494