Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections

•Prior COVID-19 vaccination is associated with lower risk of many but not all COVID-19 sequelae.•The risks of ICU admission, thromboembolism, and psychotic disorders (among others) were lower.•Risks of anxiety, depression, sleep disorder, renal disease and long COVID features did not differ.•Receivi...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2022-07, Vol.103, p.154-162
Main Authors: Taquet, Maxime, Dercon, Quentin, Harrison, Paul J.
Format: Article
Language:English
Subjects:
Cohort studies
COVID-19 - complications
COVID-19 outcomes
COVID-19 Vaccines
Disease Progression
Electronic health records
Humans
Middle Aged
Post-Acute COVID-19 Syndrome
Retrospective Studies
SARS-CoV-2
Vaccination
Vaccine
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Summary:•Prior COVID-19 vaccination is associated with lower risk of many but not all COVID-19 sequelae.•The risks of ICU admission, thromboembolism, and psychotic disorders (among others) were lower.•Risks of anxiety, depression, sleep disorder, renal disease and long COVID features did not differ.•Receiving two vaccine doses was associated with lower risks for most outcomes.•Age had a significant impact on reduction in risk of COVID-19 outcomes with vaccination. Vaccination has proven effective against infection with SARS-CoV-2, as well as death and hospitalisation following COVID-19 illness. However, little is known about the effect of vaccination on other acute and post-acute outcomes of COVID-19. Data were obtained from the TriNetX electronic health records network (over 81 million patients mostly in the USA). Using a retrospective cohort study and time-to-event analysis, we compared the incidences of COVID-19 outcomes between individuals who received a COVID-19 vaccine (approved for use in the USA) at least 2 weeks before SARS-CoV-2 infection and propensity score-matched individuals unvaccinated for COVID-19 but who had received an influenza vaccine. Outcomes were ICD-10 codes representing documented COVID-19 sequelae in the 6 months after a confirmed SARS-CoV-2 infection (recorded between January 1 and August 31, 2021, i.e. before the emergence of the Omicron variant). Associations with the number of vaccine doses (1 vs. 2) and age (
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2022.04.013