Acute Exercise with Moderate Hypoxia Reduces Arterial Oxygen Saturation and Cerebral Oxygenation without Affecting Hemodynamics in Physically Active Males

• Published in: International journal of environmental research and public health 2022-04, Vol.19 (8), p.4558
• Main Authors: Mulliri, Gabriele, Magnani, Sara, Roberto, Silvana, Ghiani, Giovanna, Sechi, Fabio, Fanni, Massimo, Marini, Elisabetta, Stagi, Silvia, Lai, Ylenia, Rinaldi, Andrea, Isola, Raffaella, Vargiu, Romina, Spranger, Marty D, Crisafulli, Antonio
• Format: Article
• Language: English
• Subjects: Adult; Altitude; Blood pressure; Cardiac output; Cardiac stress tests; Cardiovascular system; Coronary vessels; Electric currents; Exercise - physiology; Exercise Test; Heart rate; Hemodynamic responses; Hemodynamics; Hemodynamics - physiology; Humans; Hypoxia; Infrared spectra; Infrared spectroscopy; Laboratories; Male; Near infrared radiation; Oxygen; Oxygen Consumption - physiology; Oxygen content; Oxygen Saturation; Oxygenation; Pulmonary arteries; Sea level; Stroke volume; Ventricle; Workloads; Young Adult
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph19084558

Hemodynamic changes during exercise in acute hypoxia (AH) have not been completely elucidated. The present study aimed to investigate hemodynamics during an acute bout of mild, dynamic exercise during moderate normobaric AH. Twenty-two physically active, healthy males (average age; range 23-40 years) completed a cardiopulmonary test on a cycle ergometer to determine their maximum workload (W ). On separate days, participants performed two randomly assigned exercise tests (three minutes pedaling at 30% of W ): (1) during normoxia (NORMO), and (2) during normobaric AH at 13.5% inspired oxygen (HYPO). Hemodynamics were assessed with impedance cardiography, and peripheral arterial oxygen saturation (SatO ) and cerebral oxygenation (Cox) were measured by near-infrared spectroscopy. Hemodynamic responses (heart rate, stroke volume, cardiac output, mean arterial blood pressure, ventricular emptying rate, and ventricular filling rate) were not any different between NORMO and HYPO. However, the HYPO test significantly reduced both SatO (96.6 ± 3.3 vs. 83.0 ± 4.5%) and Cox (71.0 ± 6.6 vs. 62.8 ± 7.4 A.U.) when compared to the NORMO test. We conclude that an acute bout of mild exercise during acute moderate normobaric hypoxia does not induce significant changes in hemodynamics, although it can cause significant reductions in SatO and Cox.