Loading…

A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3- f ]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3- f ]pyrimido[4,5- b ]quinolines via selective multiple C-C bond formation under metal-free conditions

A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1' -spiro[pyrazolo[4,3- ]quinoline-8,5'-pyrimidine]-2',4',6'(3' )-triones (d.r. up to 20 : 1 (  :  )) and tetrahydro-8 -pyrazolo[4,3- ]pyrimido[4,5...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2020-05, Vol.10 (33), p.19600-19609
Main Authors: Patel, Divyang M, Patel, Hetal J, Padrón, José M, Patel, Hitendra M
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1' -spiro[pyrazolo[4,3- ]quinoline-8,5'-pyrimidine]-2',4',6'(3' )-triones (d.r. up to 20 : 1 (  :  )) and tetrahydro-8 -pyrazolo[4,3- ]pyrimido[4,5- ]quinoline-8,10(9 )-diones formation of selective multiple C-C bonds under identical reaction conditions ( ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra02990d