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A novel substrate directed multicomponent reaction for the syntheses of tetrahydro-spiro[pyrazolo[4,3- f ]quinoline]-8,5'-pyrimidines and tetrahydro-pyrazolo[4,3- f ]pyrimido[4,5- b ]quinolines via selective multiple C-C bond formation under metal-free conditions
A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1' -spiro[pyrazolo[4,3- ]quinoline-8,5'-pyrimidine]-2',4',6'(3' )-triones (d.r. up to 20 : 1 ( : )) and tetrahydro-8 -pyrazolo[4,3- ]pyrimido[4,5...
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Published in: | RSC advances 2020-05, Vol.10 (33), p.19600-19609 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A versatile and substrate oriented multicomponent reaction for the syntheses of novel highly diastereoselective tetrahydro-1'
-spiro[pyrazolo[4,3-
]quinoline-8,5'-pyrimidine]-2',4',6'(3'
)-triones (d.r. up to 20 : 1 (
:
)) and tetrahydro-8
-pyrazolo[4,3-
]pyrimido[4,5-
]quinoline-8,10(9
)-diones
formation of selective multiple C-C bonds under identical reaction conditions (
ethanol as a reaction medium and deep eutectic mixture as a catalyst) is demonstrated. Both approaches involve mild reaction conditions, use of non-hazardous solvents, and facilitate good to excellent reaction yields of the target compounds. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d0ra02990d |