The virota and its transkingdom interactions in the healthy infant gut

SignificanceMicrobes colonizing the infant gut during the first year(s) of life play an important role in immune system development. We show that after birth the (nearly) sterile gut is rapidly colonized by bacteria and their viruses (phages), which often show a strong cooccurrence. Most viruses inf...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2022-03, Vol.119 (13), p.e2114619119-e2114619119
Main Authors: Beller, Leen, Deboutte, Ward, Vieira-Silva, Sara, Falony, Gwen, Tito, Raul Yhossef, Rymenans, Leen, Yinda, Claude Kwe, Vanmechelen, Bert, Van Espen, Lore, Jansen, Daan, Shi, Chenyan, Zeller, Mark, Maes, Piet, Faust, Karoline, Van Ranst, Marc, Raes, Jeroen, Matthijnssens, Jelle
Format: Article
Language:English
Subjects:
Babies
Bacteria
Bacteriophages
Biological Sciences
Birth
Feces
Gastroenteritis
Gastrointestinal Microbiome
Genomes
Humans
Infant
Infants
Intestinal microflora
Microbiota
Parasites
Perturbation
Phages
Plant viruses
Population studies
Temporal resolution
Viruses
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Summary:SignificanceMicrobes colonizing the infant gut during the first year(s) of life play an important role in immune system development. We show that after birth the (nearly) sterile gut is rapidly colonized by bacteria and their viruses (phages), which often show a strong cooccurrence. Most viruses infecting the infant do not cause clinical signs and their numbers strongly increase after day-care entrance. The infant diet is clearly reflected by identification of plant-infecting viruses, whereas fungi and parasites are not part of a stable gut microbiota. These temporal high-resolution baseline data about the gut colonization process will be valuable for further investigations of pathogenic viruses, dynamics between phages and their bacterial host, as well as studies investigating infants with a disturbed microbiota.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2114619119