Increased macrophage activation marker soluble CD163 is associated with graft dysfunction and metabolic derangements in renal transplant recipients

Renal allograft is vulnerable to numerous insults and is associated with metabolic derangements. Macrophages are regulators of inflammation and play a role in obesity, lipid metabolism and insulin resistance (IR). The present study was designed to assess macrophage activation, reflected by serum sol...

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Bibliographic Details
Published in:Biomedical journal 2021-12, Vol.44 (6 Suppl 2), p.S179-S189
Main Authors: El Aggan, Hayam, Mahmoud, Sabah, El Shair, Heba, Elabd, Hazem
Format: Article
Language:English
Subjects:
Adult
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Biomarkers
C-Reactive Protein - metabolism
Female
Humans
Insulin Resistance - physiology
Kidney - metabolism
Kidney Transplantation - adverse effects
Macrophage Activation - physiology
Male
Middle Aged
Original
Receptors, Cell Surface
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Summary:Renal allograft is vulnerable to numerous insults and is associated with metabolic derangements. Macrophages are regulators of inflammation and play a role in obesity, lipid metabolism and insulin resistance (IR). The present study was designed to assess macrophage activation, reflected by serum soluble CD163 (sCD163), in renal transplant recipients (RTR) and its relation to chronic allograft dysfunction (CAD) and metabolic derangements. Fifty recipients of renal transplantation (RT) [22 with stable renal function and 28 with CAD] and 20 age- and sex-matched healthy controls were enrolled in the study. Serum sCD163 and high sensitivity C-reactive protein (hsCRP) were measured using enzyme-linked immunosorbent assay. Anthropometric measurements, renal function, lipid profile and homeostatic model assessment of IR (HOMA-IR) were estimated. Renal interstitial fibrosis (IF) was graded in renal biopsies of CAD. RTR mean age was 38.84 ± 9.28 years and 83% of them were males. Post-transplant dyslipidemia, diabetes and IR (HOMA-IR >2) were present in 42%, 24% and 86% of RTR respectively. Serum sCD163 levels were significantly higher in RTR with stable renal function and CAD than in healthy controls (814.41 ± 59.62 ng/ml and 1021.21 ± 120.82 ng/ml vs. 602.90 ± 114.98 ng/ml respectively) and in RTR with CAD than in patients with stable renal function (p 
ISSN:2319-4170
2320-2890
DOI:10.1016/j.bj.2020.09.004