Radiotherapy for HPV-related cancers: prediction of therapeutic effects based on the mechanism of tumor immunity and the application of immunoradiotherapy

Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In...

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Bibliographic Details
Published in:Japanese journal of radiology 2022-05, Vol.40 (5), p.458-465
Main Authors: Someya, Masanori, Fukushima, Yuki, Hasegawa, Tomokazu, Tsuchiya, Takaaki, Kitagawa, Mio, Gocho, Toshio, Mafune, Shoh, Ikeuchi, Yutaro, Kozuka, Yoh, Hirohashi, Yoshihiko, Torigoe, Toshihiko, Iwasaki, Masahiro, Matsuura, Motoki, Saito, Tsuyoshi, Sakata, Koh-ichi
Format: Article
Language:English
Subjects:
Alphapapillomavirus
Female
Humans
Imaging
Invited Review
Medicine
Medicine & Public Health
Neoplasms - radiotherapy
Nuclear Medicine
Papillomaviridae
Papillomavirus Infections - complications
Papillomavirus Infections - drug therapy
Radioimmunotherapy
Radiology
Radiotherapy
Uterine Cervical Neoplasms
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Summary:Human papillomavirus (HPV)-related cancer is one of the diseases entities for which the applications of radiotherapy have been increasing. Recently, the process of carcinogenesis from HPV infection and the mechanism of tumor immunity that develops during disease progression have been elucidated. In this review, we will describe the mechanism of tumor immunity and how chemoradiotherapy may overcome and improve the efficacy of tumor immunity. We will also discuss the usefulness of proteins involved with tumor immunity as a predictive marker of radiotherapy response, and present an overview of ongoing clinical trials of combinations of immune checkpoint inhibitors and radiotherapy to demonstrate the promising combination therapy that has been currently emerging.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-021-01231-4