Risk factors for acute exacerbation of interstitial lung disease following lung cancer resection: a systematic review and meta-analysis

• Published in: Interactive cardiovascular and thoracic surgery 2022-05, Vol.34 (5), p.744-752
• Main Authors: Hao, Xiaohu, Hao, Jianqi, Chen, Cong, Peng, Haoning, Zhang, Jian, Cao, Qi, Liu, Lunxu
• Format: Article
• Language: English
• Subjects: Humans; Lactate Dehydrogenases; Lung Diseases, Interstitial - diagnosis; Lung Diseases, Interstitial - etiology; Lung Neoplasms - surgery; Male; Oxygen; Prognosis; Retrospective Studies; Risk Factors; Thoracic
• ISSN: 1569-9285; 1569-9293; 1569-9285
• DOI: 10.1093/icvts/ivab350

Abstract OBJECTIVES The aim of this study was to investigate the risk factors for acute exacerbation (AE) of interstitial lung disease (ILD) following lung cancer resection. METHODS We performed a literature screening on the databases including PubMed, Embase, Ovid MEDLINE® and the Web of Science for related studies published up to January 2021. Eligible studies were included and data on risk factors related to postoperative AE were extracted. All analyses were performed with random-effect model. RESULTS A total of 12 studies of 2655 lung cancer patients with ILD were included in this article. The meta-analysis indicated that male [odds ratios (ORs) = 1.78, 95% confidence interval (CI): 1.02–3.11, P = 0.041], usually interstitial pneumonia pattern on CT (OR = 1.52, 95% CI: 1.06–2.17, P = 0.021), Krebs von den Lungen-6 [standardized mean difference (SMD) = 0.50, 95% CI: 0.06–0.94, P = 0.027], white blood cell (SMD = 0.53, 95% CI: 0.12–0.93, P = 0.010), lactate dehydrogenase (SMD = 0.47, 95% CI: 0.04–0.90, P = 0.032), partial pressure of oxygen (weighted mean difference = −3.09, 95% CI: −5.99 to −0.19, P = 0.037), surgery procedure (OR = 2.31, 95% CI: 1.42–3.77, P