Use of aminoglycosides in treatment of infections due to intracellular bacteria

Streptomycin was successfully used to treat infections due to facultative intracellular pathogens, such as tuberculosis (especially tuberculous meningitis), plague, brucellosis, or tularemia. As for tuberculosis, clinical data were concordant with the demonstration by Mackaness et al. that streptomy...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2001-11, Vol.45 (11), p.2977-2986
Main Authors: MAURIN, M, RAOULT, D
Format: Article
Language:English
Subjects:
Aminoglycosides
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Bacterial Infections - pathology
Bartonella bacilliformis
Biological and medical sciences
Francisella tularensis
Humans
Medical sciences
Minireview
Minireviews
Mycobacterium tuberculosis
Phagocytes - drug effects
Phagocytes - microbiology
Pharmacology. Drug treatments
Yersinia pestis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptomycin was successfully used to treat infections due to facultative intracellular pathogens, such as tuberculosis (especially tuberculous meningitis), plague, brucellosis, or tularemia. As for tuberculosis, clinical data were concordant with the demonstration by Mackaness et al. that streptomycin could inhibit growth of Mycobacterium tuberculosis within macrophages. Both these clinical and experimental data have been overlooked for several decades. Later experiments by Tulkens et al. have confirmed that aminoglycosides are readily incorporated into phagocytes when these cells are in contact with the antibiotic for prolonged periods (i.e., more than 24 h). The present review deals with the potential role of aminoglycosides, and especially streptomycin, in the antibiotic therapy of infections due to intracellular pathogens. Our goal is to highlight the concept that categorization of aminoglycosides as strictly ineffective against intracellular pathogens is in some ways too simplistic and does not correspond to clinical experience, since aminoglycosides remain in fact a 'gold standard' therapy in a number of infections due to intracellularly surviving pathogens.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.45.11.2977-2986.2001