The synthesis of imidazo[1,5- a ]quinolines via a decarboxylative cyclization under metal-free conditions

An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5- ]quinolines with moderate to good yields.

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (41), p.23058-23065
Main Authors: Yan, Zicong, Wan, Changfeng, Yang, Yu, Zha, Zhenggen, Wang, Zhiyong
Format: Article
Language:English
Subjects:
Amino acids
Chemistry
Iodine
Organic compounds
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Description
Summary:An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5- ]quinolines with moderate to good yields.
ISSN:2046-2069
2046-2069
DOI:10.1039/c8ra03786h