Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort

Background Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods We utilised a case-cohort design consist...

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Bibliographic Details
Published in:British journal of cancer 2022-06, Vol.126 (10), p.1481-1489
Main Authors: Suzuki, Shiori, Katagiri, Ryoko, Yamaji, Taiki, Sawada, Norie, Imatoh, Takuya, Ihira, Hikaru, Inoue, Manami, Tsugane, Shoichiro, Iwasaki, Motoki
Format: Article
Language:English
Subjects:
692/499
692/53
692/699/67/2324
Biliary tract
Biomedical and Life Sciences
Biomedicine
Breast
C-reactive protein
C-Reactive Protein - metabolism
Cancer
Cancer Research
Drug Resistance
Epidemiology
Female
Humans
Inflammation
Inflammation - complications
Japan - epidemiology
Kidney cancer
Kidney Neoplasms
Leukemia
Male
Molecular Medicine
Oncology
Population studies
Proportional Hazards Models
Prospective Studies
Risk Factors
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Summary:Background Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods We utilised a case-cohort design consisting of multi-types of cancer ( N  = 3608), and a random subcohort ( N  = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP using high sensitivity assay. The hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods. Results The multivariable-adjusted HR (95% confidence interval) for the top quartile of CRP was 1.28 (1.11‒1.48) ( P trend  3 years’ follow-up. Furthermore, subgroup analyses for overall cancer robustly showed a positive association with CRP levels, regardless of sex and obesity. Conclusion Our consistent findings suggested that chronic low-grade inflammation measured by CRP is associated with the risk of cancer.
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-022-01715-8