Structural Aspects of Electrospun Scaffolds Intended for Prosthetics of Blood Vessels

Electrospinning is a popular method used to fabricate small-diameter vascular grafts. However, the importance of structural characteristics of the scaffold determining interaction with endothelial cells and their precursors and blood cells is still not exhaustively clear. This review discusses curre...

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Bibliographic Details
Published in:Polymers 2022-04, Vol.14 (9), p.1698
Main Authors: Chernonosova, Vera S, Laktionov, Pavel P
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Blood cells
Blood vessels
Cell adhesion & migration
Cytoskeleton
Electrospinning
Endothelial cells
Endothelium
Kinases
Microscopy
Morphology
Polyethylene terephthalate
Polymerization
Pore size
Prostheses
Review
Scaffolds
Smooth muscle
Surface roughness
Topography
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Summary:Electrospinning is a popular method used to fabricate small-diameter vascular grafts. However, the importance of structural characteristics of the scaffold determining interaction with endothelial cells and their precursors and blood cells is still not exhaustively clear. This review discusses current research on the significance and impact of scaffold architecture (fiber characteristics, porosity, and surface roughness of material) on interactions between cells and blood with the material. In addition, data about the effects of scaffold topography on cellular behaviour (adhesion, proliferation, and migration) are necessary to improve the rational design of electrospun vascular grafts with a long-term perspective.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14091698