Severity and Incidence of Multisystem Inflammatory Syndrome in Children During 3 SARS-CoV-2 Pandemic Waves in Israel

Levy et al present their study which describes outcomes of multisystem inflammatory syndrome in children (MIS-C) in a multicenter cohort and assessed incidence nationally during the Alpha, Delta, and Omicron variant waves. To assess cardiac involvement and admission to the intensive care unit (ICU)...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2022-06, Vol.327 (24), p.2452-2454
Main Authors: Levy, Nitai, Koppel, Jordanna H, Kaplan, Or, Yechiam, Hadas, Shahar-Nissan, Keren, Cohen, Naama Kuchinski, Shavit, Itai
Format: Article
Language:English
Subjects:
Children
COVID-19
Hospitals
Inflammation
Letter
Letters
Online First
Pandemics
Patients
Research Letter
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccination
Viral diseases
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Summary:Levy et al present their study which describes outcomes of multisystem inflammatory syndrome in children (MIS-C) in a multicenter cohort and assessed incidence nationally during the Alpha, Delta, and Omicron variant waves. To assess cardiac involvement and admission to the intensive care unit (ICU) in patients with MIS-C, a prospective study was conducted in 12 Israeli hospitals over a 16-week period of each pandemic wave. In the 12 participating hospitals, 171 patients with a median (IQR) age of 8 (5-12) years were diagnosed with MIS-C; 59 during the Alpha wave, 79 during the Delta wave, and 33 during the Omicron wave. Their study suggests that MIS-C during the Omicron wave was less severe than during the Alpha or Delta waves of the COVID-19 pandemic. Possible explanations include the Omicron variant itself, previous infection with SARS-CoV-2, vaccination against SARS-CoV-2, and improvement in treatment over time.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2022.8025