Amelioration of oxidative damage parameters by carvacrol on methanol-induced liver injury in rats

The methanol metabolite that causes hepatotoxicity is formic acid, generating reactive oxygen radical formation and cell damage. Carvacrol is an antioxidant monoterpenic phenol produced from Thymus vulgaris. This study aimed to investigate the effects of carvacrol on methanol-induced oxidative liver...

Full description

Saved in:
Bibliographic Details
Published in:Experimental Animals 2022, Vol.71(2), pp.224-230
Main Authors: Gursul, Cebrail, Ozcicek, Adalet, Ozkaraca, Mustafa, Mendil, Ali Sefa, Coban, Taha Abdulkadir, Arslan, Aynur, Ozcicek, Fatih, Suleyman, Halis
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Antioxidants
Aspartate aminotransferase
Biochemical markers
Carvacrol
Damage
Degeneration
Distilled water
experimental models
Formic acid
Glutathione
Hemorrhage
Hepatotoxicity
Liver
liver injury
Metabolites
Methanol
Methotrexate
Oral administration
Original
Oxidants
oxidative damage
Oxidizing agents
Phenols
Pycnosis
Transaminases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The methanol metabolite that causes hepatotoxicity is formic acid, generating reactive oxygen radical formation and cell damage. Carvacrol is an antioxidant monoterpenic phenol produced from Thymus vulgaris. This study aimed to investigate the effects of carvacrol on methanol-induced oxidative liver damage in rats. Eighteen rats were divided into three groups. Methotrexate was administered orally for 7 days to methotrexate+methanol (MTM) and methotrexate+methanol+carvacrol (MMC) groups. Methotrexate was given before methanol to cause methanol poisoning. Distilled water was given to the healthy group (HG) as a solvent. At the end of the 7th day, 20% methanol was administered orally at a dose of 3 g/kg to the MTM and MMC groups. Four hours after methanol administration, 50 mg/kg carvacrol was injected intraperitoneally into the MMC group. Animals were sacrificed 8 h after carvacrol injection. Biochemical markers were studied in the excised liver tissue and blood serum samples, and histopathological evaluations were made. Severe hemorrhage, hydropic degeneration, pycnosis, and mononuclear cell infiltration were observed in the liver of the MTM group. Additionally, the levels of malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were significantly higher, and total glutathione (tGSH) and total antioxidant status (TAS) were significantly lower in the MTM group compared to HG (P
ISSN:1341-1357
1881-7122
DOI:10.1538/expanim.21-0143