Research on the Guiding Effect of CTCs on Postoperative Adjuvant Therapy for Patients with Early Stage Endometrial Cancer

Endometrial tumor has increased in occurrence and fatality in China during the last 11 years, owing to inconsistent hormone use and modifications in people living surrounding and lifestyles. One of the three main gynaecological tumors is endometrial carcinoma (EC). Longer waiting duration of operati...

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Bibliographic Details
Published in:Journal of oncology 2022, Vol.2022, p.4327977-9
Main Authors: Li, Liguo, Zhai, Huihui, Zhang, Qiumei, Feng, Yuan, Yang, Chunhui, Li, Hong, He, Hongfen
Format: Article
Language:English
Subjects:
Adjuvant treatment
Analysis
Biomarkers
Biopsy
Body fat
Cancer
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Development and progression
Disease
Endometrial cancer
Fatalities
Identification
Metastasis
Oncology, Experimental
Overweight
Patients
Radiation therapy
Researchers
Sustainability
Sustainable development
Vagina
Womens health
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Summary:Endometrial tumor has increased in occurrence and fatality in China during the last 11 years, owing to inconsistent hormone use and modifications in people living surrounding and lifestyles. One of the three main gynaecological tumors is endometrial carcinoma (EC). Longer waiting duration of operation was linked to a lower chance of sustainability in endometrial tumor patients. Despite the great sustainability rate of endometrial tumor, only around 46 percent of patients undergo adjuvant treatment. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and circulating free DNA (cfDNA) are the most investigated tumor noninvasive indicators. These circulating biomarkers are important in the knowledge of metastasis and tumorigenesis, and they could help researchers comprehend how cancer dynamics evolve throughout the therapy and illness development. In patients with solid tumor, the existence of circulating tumor cells (CTCs) in the peripheral blood is linked to a weak prognosis. However, there is a scarcity of information on how to detect CTCs in endometrial cancer (EC). Hence, in this paper, we analyze the guiding effect of CTCs on postoperative adjuvant treatment for sufferers with initial phase endometrial tumor using multi-cox regression method. The dataset is selected and the blood samples are collected using plasma separation method. The CTC is detected using differential diagnosis. The morphology and biological features, Immunocytochemistry, Genomic analysis, Transcriptomic analysis, Proteomic analysis, and molecular analysis are performed and the outcomes are evaluated.
ISSN:1687-8450
1687-8450
DOI:10.1155/2022/4327977