Serum Zonulin Levels in Hypothyroid and Euthyroid Patients with Hashimoto’s Thyroiditis – a Pilot Study

• Published in: Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2021-10, Vol.17 (4), p.449-454
• Main Author: Tomov, D
• Format: Article
• Language: English
• Subjects: General Endocrinology
• ISSN: 1841-0987; 1843-066X
• DOI: 10.4183/aeb.2021.449

ContextHuman zonulin is a protein that regulates the intercellular tight junctions in various tissues and organs of the human body. Hashimoto's thyroiditis (HT) is one of the most common endocrine autoimmune disorder, but the role of increased intestinal permeability in its pathogenesis is still being studied. Objective and designThis pilot cross-sectional study investigates serum zonulin concentration in adults with Hashimoto's thyroiditis and assesses the relationship between zonulin levels, clinical hormonal and immunological characteristics. Subjects and methodsA group of 62 adults with HT participated in this study and were divided into three groups: hypothyroid (n=33) euthyroid (n=25) and hyperthyroid (n=4). Serum zonulin was determined using an ELISA method. ResultsAge, gender and BMI were different between groups (hypothyroid and euthyroid ones). Serum zonulin values ranged from 2.6 to 198.0 ng/mL in participants. A direct positive correlation was found between serum zonulin levels and weight and BMI (r = 0.351, p = 0.008 and r = 0.236, p = 0.05, respectively). ConclusionsThere is no correlation between zonulin and thyroid hormones or autoantibodies in Hashimoto thyroiditis patients. There is a difference in zonulin levels between the studied groups, but they are not statistically significant.