The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival

Glioma is a highly fatal cancer with prognostically significant molecular subtypes and few known risk factors. Multiple studies have implicated infections in glioma susceptibility, but evidence remains inconsistent. Genetic variants in the human leukocyte antigen (HLA) region modulate host response...

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Bibliographic Details
Published in:American journal of human genetics 2022-06, Vol.109 (6), p.1105-1116
Main Authors: Guerra, Geno, Kachuri, Linda, Wendt, George, Hansen, Helen M., Mack, Steven J., Molinaro, Annette M., Rice, Terri, Bracci, Paige, Wiencke, John K., Kasahara, Nori, Eckel-Passow, Jeanette E., Jenkins, Robert B., Wrensch, Margaret, Francis, Stephen S.
Format: Article
Language:English
Subjects:
Antigens, Viral
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
glioma
Glioma - complications
Glioma - genetics
Herpesvirus 4, Human - genetics
human leukocyte antigen
Humans
Immunogenetics
Merkel cell polyomavirus
Multiple Sclerosis - genetics
polygenic risk score
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Summary:Glioma is a highly fatal cancer with prognostically significant molecular subtypes and few known risk factors. Multiple studies have implicated infections in glioma susceptibility, but evidence remains inconsistent. Genetic variants in the human leukocyte antigen (HLA) region modulate host response to infection and have been linked to glioma risk. In this study, we leveraged genetic predictors of antibody response to 12 viral antigens to investigate the relationship with glioma risk and survival. Genetic reactivity scores (GRSs) for each antigen were derived from genome-wide-significant (p 
ISSN:0002-9297
1537-6605
1537-6605
DOI:10.1016/j.ajhg.2022.04.011