Association between Oxidative Burden and Restenosis: A Case-Control Study

Background. In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number...

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Published in:Oxidative medicine and cellular longevity 2022, Vol.2022, p.3577761-10
Main Authors: Ganjali, Shiva, Mansouri, Atena, Abbasifard, Mitra, Moallem, Seyed Adel, Tayarani-Najaran, Zahra, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Angioplasty
Antioxidants
Case-Control Studies
Cholesterol
Constriction, Pathologic - complications
Coronary Angiography - adverse effects
Coronary Restenosis
Enzymes
Glucose
High density lipoprotein
Humans
Hypertension
Lipoproteins
Nonsteroidal anti-inflammatory drugs
Oxidative stress
Risk Factors
Statistical analysis
Stents
Sulfhydryl Compounds
Superoxide Dismutase
Treatment Outcome
Triglycerides
Variance analysis
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Summary:Background. In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number of these patients continues to rise, it is pivotal to detect patients who are at a higher risk of ISR. In addition, identification of biochemical markers of ISR could give the right perspective on choosing the proper strategy to treat these patients. Several pathophysiological pathways including oxidative stress (OS) are implicated in the progression of ISR. Hence, this study aimed to evaluate the association between oxidative/anti-oxidative markers and ISR. Methods. This was a case-control study which comprised 21 ISR, 26 NISR (non-ISR), and 20 healthy subjects. The serum levels of OS markers including malondialdehyde (MDA), thiol groups (GSH), total antioxidant capacity (TAC), and the activity of serum antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) were assessed by colorimetric methods. The overall oxidative burden was assessed using a pro-oxidant-antioxidant balance (PAB) assay. Results. MDA levels were considerably higher in the ISR group when compared to healthy subjects (P=0.004). PAB also indicated significantly higher values in both ISR (P
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/3577761