Association between Oxidative Burden and Restenosis: A Case-Control Study

Background. In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number...

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Published in:Oxidative medicine and cellular longevity 2022, Vol.2022, p.3577761-10
Main Authors: Ganjali, Shiva, Mansouri, Atena, Abbasifard, Mitra, Moallem, Seyed Adel, Tayarani-Najaran, Zahra, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Angioplasty
Antioxidants
Case-Control Studies
Cholesterol
Constriction, Pathologic - complications
Coronary Angiography - adverse effects
Coronary Restenosis
Enzymes
Glucose
High density lipoprotein
Humans
Hypertension
Lipoproteins
Nonsteroidal anti-inflammatory drugs
Oxidative stress
Risk Factors
Statistical analysis
Stents
Sulfhydryl Compounds
Superoxide Dismutase
Treatment Outcome
Triglycerides
Variance analysis
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container_start_page 3577761
container_title Oxidative medicine and cellular longevity
container_volume 2022
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Mansouri, Atena
Abbasifard, Mitra
Moallem, Seyed Adel
Tayarani-Najaran, Zahra
Sahebkar, Amirhossein
description Background. In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number of these patients continues to rise, it is pivotal to detect patients who are at a higher risk of ISR. In addition, identification of biochemical markers of ISR could give the right perspective on choosing the proper strategy to treat these patients. Several pathophysiological pathways including oxidative stress (OS) are implicated in the progression of ISR. Hence, this study aimed to evaluate the association between oxidative/anti-oxidative markers and ISR. Methods. This was a case-control study which comprised 21 ISR, 26 NISR (non-ISR), and 20 healthy subjects. The serum levels of OS markers including malondialdehyde (MDA), thiol groups (GSH), total antioxidant capacity (TAC), and the activity of serum antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) were assessed by colorimetric methods. The overall oxidative burden was assessed using a pro-oxidant-antioxidant balance (PAB) assay. Results. MDA levels were considerably higher in the ISR group when compared to healthy subjects (P=0.004). PAB also indicated significantly higher values in both ISR (P
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In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number of these patients continues to rise, it is pivotal to detect patients who are at a higher risk of ISR. In addition, identification of biochemical markers of ISR could give the right perspective on choosing the proper strategy to treat these patients. Several pathophysiological pathways including oxidative stress (OS) are implicated in the progression of ISR. Hence, this study aimed to evaluate the association between oxidative/anti-oxidative markers and ISR. Methods. This was a case-control study which comprised 21 ISR, 26 NISR (non-ISR), and 20 healthy subjects. The serum levels of OS markers including malondialdehyde (MDA), thiol groups (GSH), total antioxidant capacity (TAC), and the activity of serum antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) were assessed by colorimetric methods. The overall oxidative burden was assessed using a pro-oxidant-antioxidant balance (PAB) assay. Results. MDA levels were considerably higher in the ISR group when compared to healthy subjects (P=0.004). PAB also indicated significantly higher values in both ISR (P&lt;0.001) and NISR (P&lt;0.001) groups related to healthy subjects. No significant differences were observed between the studied groups regarding thiol levels, antioxidant enzyme activities, and TAC. Multinomial logistic regression analysis showed that elevated serum levels of MDA (OR: 1.028, 95% CI: 1.008-1.048; P=0.006) and PAB (OR: 1.076, 95% CI: 1.017-1.139; P=0.011) were significantly associated with higher ISR risk; however, increased values of TAC (OR: 0.990, 95% CI: 0.982-0.999; P=0.030) were significantly associated with decreased ISR risk, while after adjustment for confounders, only SOD activity (OR: 0.0, 95% CI: 0.0-0.0; P&lt;0.001) and PAB value (OR: 1.866, 95% CI: 1.856-1.900; P&lt;0.001) showed association with ISR risk. Conclusion. According to the present findings, some oxidative and antioxidative markers like PAB and SOD activity showed the potential in the prediction of ISR risk.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2022/3577761</identifier><identifier>PMID: 35799893</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Angioplasty ; Antioxidants ; Case-Control Studies ; Cholesterol ; Constriction, Pathologic - complications ; Coronary Angiography - adverse effects ; Coronary Restenosis ; Enzymes ; Glucose ; High density lipoprotein ; Humans ; Hypertension ; Lipoproteins ; Nonsteroidal anti-inflammatory drugs ; Oxidative stress ; Risk Factors ; Statistical analysis ; Stents ; Sulfhydryl Compounds ; Superoxide Dismutase ; Treatment Outcome ; Triglycerides ; Variance analysis</subject><ispartof>Oxidative medicine and cellular longevity, 2022, Vol.2022, p.3577761-10</ispartof><rights>Copyright © 2022 Shiva Ganjali et al.</rights><rights>Copyright © 2022 Shiva Ganjali et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Shiva Ganjali et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-a185d4ba80bb13db1e9403b79c0a0c084ca4fab2f274c0ac0a4fdad6025c79d63</citedby><cites>FETCH-LOGICAL-c448t-a185d4ba80bb13db1e9403b79c0a0c084ca4fab2f274c0ac0a4fdad6025c79d63</cites><orcidid>0000-0002-8656-1444 ; 0000-0003-4670-7127</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2687527428?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2687527428?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,4009,25732,27902,27903,27904,36991,38495,43874,44569,74159,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35799893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cao, Jianlei</contributor><contributor>Jianlei Cao</contributor><creatorcontrib>Ganjali, Shiva</creatorcontrib><creatorcontrib>Mansouri, Atena</creatorcontrib><creatorcontrib>Abbasifard, Mitra</creatorcontrib><creatorcontrib>Moallem, Seyed Adel</creatorcontrib><creatorcontrib>Tayarani-Najaran, Zahra</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><title>Association between Oxidative Burden and Restenosis: A Case-Control Study</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Background. In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number of these patients continues to rise, it is pivotal to detect patients who are at a higher risk of ISR. In addition, identification of biochemical markers of ISR could give the right perspective on choosing the proper strategy to treat these patients. Several pathophysiological pathways including oxidative stress (OS) are implicated in the progression of ISR. Hence, this study aimed to evaluate the association between oxidative/anti-oxidative markers and ISR. Methods. This was a case-control study which comprised 21 ISR, 26 NISR (non-ISR), and 20 healthy subjects. The serum levels of OS markers including malondialdehyde (MDA), thiol groups (GSH), total antioxidant capacity (TAC), and the activity of serum antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) were assessed by colorimetric methods. The overall oxidative burden was assessed using a pro-oxidant-antioxidant balance (PAB) assay. Results. MDA levels were considerably higher in the ISR group when compared to healthy subjects (P=0.004). PAB also indicated significantly higher values in both ISR (P&lt;0.001) and NISR (P&lt;0.001) groups related to healthy subjects. No significant differences were observed between the studied groups regarding thiol levels, antioxidant enzyme activities, and TAC. Multinomial logistic regression analysis showed that elevated serum levels of MDA (OR: 1.028, 95% CI: 1.008-1.048; P=0.006) and PAB (OR: 1.076, 95% CI: 1.017-1.139; P=0.011) were significantly associated with higher ISR risk; however, increased values of TAC (OR: 0.990, 95% CI: 0.982-0.999; P=0.030) were significantly associated with decreased ISR risk, while after adjustment for confounders, only SOD activity (OR: 0.0, 95% CI: 0.0-0.0; P&lt;0.001) and PAB value (OR: 1.866, 95% CI: 1.856-1.900; P&lt;0.001) showed association with ISR risk. Conclusion. 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Mansouri, Atena ; Abbasifard, Mitra ; Moallem, Seyed Adel ; Tayarani-Najaran, Zahra ; Sahebkar, Amirhossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-a185d4ba80bb13db1e9403b79c0a0c084ca4fab2f274c0ac0a4fdad6025c79d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angioplasty</topic><topic>Antioxidants</topic><topic>Case-Control Studies</topic><topic>Cholesterol</topic><topic>Constriction, Pathologic - complications</topic><topic>Coronary Angiography - adverse effects</topic><topic>Coronary Restenosis</topic><topic>Enzymes</topic><topic>Glucose</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Lipoproteins</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oxidative stress</topic><topic>Risk Factors</topic><topic>Statistical analysis</topic><topic>Stents</topic><topic>Sulfhydryl Compounds</topic><topic>Superoxide Dismutase</topic><topic>Treatment Outcome</topic><topic>Triglycerides</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganjali, Shiva</creatorcontrib><creatorcontrib>Mansouri, Atena</creatorcontrib><creatorcontrib>Abbasifard, Mitra</creatorcontrib><creatorcontrib>Moallem, Seyed Adel</creatorcontrib><creatorcontrib>Tayarani-Najaran, Zahra</creatorcontrib><creatorcontrib>Sahebkar, Amirhossein</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; 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In-stent restenosis (ISR) is an important clinical complication that occurs following stent implantation. The application of drug-eluting stents (DES) and even consumption of drugs such as antiplatelet agents and statins are not completely effective in reducing ISR risk. Since the number of these patients continues to rise, it is pivotal to detect patients who are at a higher risk of ISR. In addition, identification of biochemical markers of ISR could give the right perspective on choosing the proper strategy to treat these patients. Several pathophysiological pathways including oxidative stress (OS) are implicated in the progression of ISR. Hence, this study aimed to evaluate the association between oxidative/anti-oxidative markers and ISR. Methods. This was a case-control study which comprised 21 ISR, 26 NISR (non-ISR), and 20 healthy subjects. The serum levels of OS markers including malondialdehyde (MDA), thiol groups (GSH), total antioxidant capacity (TAC), and the activity of serum antioxidant enzymes such as glutathione peroxidase (GPx) and superoxide dismutase (SOD) were assessed by colorimetric methods. The overall oxidative burden was assessed using a pro-oxidant-antioxidant balance (PAB) assay. Results. MDA levels were considerably higher in the ISR group when compared to healthy subjects (P=0.004). PAB also indicated significantly higher values in both ISR (P&lt;0.001) and NISR (P&lt;0.001) groups related to healthy subjects. No significant differences were observed between the studied groups regarding thiol levels, antioxidant enzyme activities, and TAC. Multinomial logistic regression analysis showed that elevated serum levels of MDA (OR: 1.028, 95% CI: 1.008-1.048; P=0.006) and PAB (OR: 1.076, 95% CI: 1.017-1.139; P=0.011) were significantly associated with higher ISR risk; however, increased values of TAC (OR: 0.990, 95% CI: 0.982-0.999; P=0.030) were significantly associated with decreased ISR risk, while after adjustment for confounders, only SOD activity (OR: 0.0, 95% CI: 0.0-0.0; P&lt;0.001) and PAB value (OR: 1.866, 95% CI: 1.856-1.900; P&lt;0.001) showed association with ISR risk. Conclusion. According to the present findings, some oxidative and antioxidative markers like PAB and SOD activity showed the potential in the prediction of ISR risk.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35799893</pmid><doi>10.1155/2022/3577761</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid><orcidid>https://orcid.org/0000-0003-4670-7127</orcidid><oa>free_for_read</oa></addata></record>
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subjects Angioplasty
Antioxidants
Case-Control Studies
Cholesterol
Constriction, Pathologic - complications
Coronary Angiography - adverse effects
Coronary Restenosis
Enzymes
Glucose
High density lipoprotein
Humans
Hypertension
Lipoproteins
Nonsteroidal anti-inflammatory drugs
Oxidative stress
Risk Factors
Statistical analysis
Stents
Sulfhydryl Compounds
Superoxide Dismutase
Treatment Outcome
Triglycerides
Variance analysis
title Association between Oxidative Burden and Restenosis: A Case-Control Study
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