Cumulative Endogenous Estrogen Exposure Is Associated With Postmenopausal Fracture Risk: The Women's Health Initiative Study

ABSTRACT We aimed to evaluate the relationship between cumulative endogenous estrogen exposure and fracture risk in 150,682 postmenopausal women (aged 50 to 79 years at baseline) who participated in the Women's Health Initiative. We hypothesized that characteristics indicating lower cumulative...

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Bibliographic Details
Published in:Journal of bone and mineral research 2022-07, Vol.37 (7), p.1260-1269
Main Authors: LeBlanc, Erin S, Hovey, Kathleen M, Cauley, Jane A, Stefanick, Marcia, Peragallo, Rachel, Naughton, Michelle J, Andrews, Christopher A, Crandall, Carolyn J
Format: Article
Language:English
Subjects:
Cockroaches
Estrogens
Estrogens - adverse effects
Female
FRACTURE
Fractures
Fractures, Bone - epidemiology
Humans
IRREGULAR MENSES
MENARCHE
MENOPAUSE
Menstruation
Post-menopause
Postmenopause
Risk Factors
Women's Health
Womens health
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Summary:ABSTRACT We aimed to evaluate the relationship between cumulative endogenous estrogen exposure and fracture risk in 150,682 postmenopausal women (aged 50 to 79 years at baseline) who participated in the Women's Health Initiative. We hypothesized that characteristics indicating lower cumulative endogenous estrogen exposure would be associated with increased fracture risk. We determined ages at menarche and menopause as well as history of irregular menses from baseline questionnaires and calculated years of endogenous estrogen exposure from ages at menarche and menopause. Incident clinical fractures were self‐reported over an average 16.7 years of follow‐up. We used multivariable proportional hazards models to assess the associations between the estrogen‐related variables and incidence of any clinical fracture. In fully adjusted models, those with the fewest years of endogenous estrogen exposure (
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.4613