Down-regulation of partial substitution for staple food by oat noodles on blood lipid levels: A randomized, double-blind, clinical trial

• Published in: Yàowu shi͡p︡in fenxi 2019-01, Vol.27 (1), p.93-100
• Main Authors: Liao, Miao-Yu, Shen, You-Cheng, Chiu, Hui-Fang, Ten, Siew-Moi, Lu, Yan-Ying, Han, Yi-Chun, Venkatakrishnan, Kamesh, Yang, Shun-Fa, Wang, Chin-Kun
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anthropometry; Avena - chemistry; Avena - metabolism; Barley; Biochemical analysis; Blood Pressure; Carbohydrates; Cardiovascular diseases; Cereals; Cholesterol; Clinical trials; Diabetes; Dietary fiber; Dietary minerals; Double-Blind Method; Double-blind studies; Down-Regulation; Female; Flour; Food; Heart diseases; High density lipoprotein; Hospitals; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - diet therapy; Hypercholesterolemia - physiopathology; Hypercholesterolemic; Hypertension; Lifestyles; Lipids; Lipids - blood; Low density lipoprotein; Male; Meals; Middle Aged; Noodles; Oat noodles; Oats; Original; Oryza - metabolism; Potassium; Proteins; Researchers; Staple food; Studies; Total cholesterol; Triticum - metabolism; Vitamins; Wheat
• ISSN: 1021-9498; 2224-6614
• DOI: 10.1016/j.jfda.2018.04.001

This clinical trial was conducted to assess the lipid-lowering activity of oat noodles by replacing partial staple food (wheat or rice noodle) in normal and mildly hypercholesterolemic subjects. Totally 84 healthy and mild hypercholesterolemic subjects were recruited and divided into 2 groups as experimental (oat noodles) and placebo (wheat noodles) and instructed to consume 100 g of oat noodles or wheat noodles (replacing one or two meals/day) for 10 weeks and followed by 2 weeks of follow up (without noodle consumption). Various anthropometric measurements and biochemical analysis were carried out during initial (baseline), 2nd, 6th, 10th and 12th week (follow-up). Consumption of oat noodles by replacing staple food for 10 weeks significantly reduced (**p