In vivo Raman spectroscopy monitors cervical change during labor

Biochemical cervical change during labor is not well understood, in part, because of a dearth of technologies capable of safely probing the pregnant cervix in vivo. The need for such a technology is 2-fold: (1) to gain a mechanistic understanding of the cervical ripening and dilation process and (2)...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2022-08, Vol.227 (2), p.275.e1-275.e14
Main Authors: Masson, Laura E., O’Brien, Christine M., Gautam, Rekha, Thomas, Giju, Slaughter, James C., Goldberg, Mack, Bennett, Kelly, Herington, Jennifer, Reese, Jeff, Elsamadicy, Emad, Newton, J. Michael, Mahadevan-Jansen, Anita
Format: Article
Language:English
Subjects:
biochemical
Cervical Ripening
Cervix Uteri - diagnostic imaging
Collagen - metabolism
Extracellular Matrix Proteins - metabolism
Female
Humans
induction
labor management
Lipids
optical
Pregnancy
preterm labor
spectroscopy
Spectrum Analysis, Raman - methods
technology
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Summary:Biochemical cervical change during labor is not well understood, in part, because of a dearth of technologies capable of safely probing the pregnant cervix in vivo. The need for such a technology is 2-fold: (1) to gain a mechanistic understanding of the cervical ripening and dilation process and (2) to provide an objective method for evaluating the cervical state to guide clinical decision-making. Raman spectroscopy demonstrates the potential to meet this need, as it is a noninvasive optical technique that can sensitively detect alterations in tissue components, such as extracellular matrix proteins, lipids, nucleic acids, and blood, which have been previously established to change during the cervical remodeling process. We sought to demonstrate that Raman spectroscopy can longitudinally monitor biochemical changes in the laboring cervix to identify spectral markers of impending parturition. Overall, 30 pregnant participants undergoing either spontaneous or induced labor were recruited. The Raman spectra were acquired in vivo at 4-hour intervals throughout labor until rupture of membranes using a Raman system with a fiber-optic probe. Linear mixed-effects models were used to determine significant (P
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2022.02.019