Obesity is a risk factor for decrease in lung function after COVID‐19 infection in children with asthma

Introduction It is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS‐CoV‐2 infection in the pediatric population and how SARS‐CoV‐2 infection affects the lung functions in these patients. Purpose We aimed to investigate the course and the consequence...

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Published in:Pediatric pulmonology 2022-07, Vol.57 (7), p.1668-1676
Main Authors: Soyak Aytekin, Elif, Sahiner, Umit M., Tuten Dal, Sevda, Unsal, Hilal, Hakverdi, Ozan, Oguz, Berna, Ozsurekci, Yasemin, Sekerel, Bulent E., Soyer, Ozge
Format: Article
Language:English
Subjects:
Asthma
Asthma - complications
Asthma - diagnosis
Asthma - epidemiology
Child
childhood
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
Humans
Infections
Lung
Multisystem inflammatory syndrome in children
Obesity
Original
Original : Asthma
Retrospective Studies
Risk Factors
SARS-CoV-2
small airway dysfunction
Systemic Inflammatory Response Syndrome
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Summary:Introduction It is not clear whether asthma, the most frequent chronic disease in childhood, is a risk for severe SARS‐CoV‐2 infection in the pediatric population and how SARS‐CoV‐2 infection affects the lung functions in these patients. Purpose We aimed to investigate the course and the consequences of SARS‐CoV‐2 infection among children with asthma and determine the risk factors for the decline in lung function tests (LFTs). Methods In this retrospective study, asthmatic children with coronavirus disease 2019 (COVID‐19) were compared with a random control group of asthmatic patients without COVID‐19. In addition, the clinical course and the effect on LFTs of COVID‐19 among children with asthma were also evaluated. Results One hundred eighty‐nine patients who had COVID‐19, and 792 who did not were included in the study. Fever, fatigue, and cough were the most frequent symptoms during COVID‐19. Regarding the severity of COVID‐19, 163 patients (87.6%) had a mild clinical condition, 13 (7%) had moderate disease, 1 (0.5%) had severe disease, and 2 had (1.1%) critically ill disease. Two patients were diagnosed with multisystem inflammatory syndrome in children (MIS‐C), one patient suffered from pneumothorax. LFTs of the patients before and after COVID‐19 infection were analyzed; no significant differences were found in FEV1% (91.7% vs. 90.9%, p = 0.513), FVC% (89.8% vs. 90.8%, p = 0.502) and FEV1/FVC (103.1% vs. 100.6%, p = 0.056), while FEF25%–75% values (107.6% vs. 98.4%, p 
ISSN:8755-6863
1099-0496
1099-0496
DOI:10.1002/ppul.25949