Antibody levels to SARS‐CoV‐2 spike protein in mothers and children from delivery to six months later

Introduction Pregnant women are vulnerable to severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) infection. Neutralizing antibodies against the SARS‐CoV‐2 spike (S) protein protect from severe disease. This study analyzes the antibody titers to SARS‐CoV‐2 S protein in pregnant women and thei...

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Published in:Birth (Berkeley, Calif.) Calif.), 2023-06, Vol.50 (2), p.418-427
Main Authors: Martin‐Vicente, María, Carrasco, Itziar, Muñoz‐Gomez, María José, Lobo, Alicia Hernanz, Mas, Vicente, Vigil‐Vázquez, Sara, Vázquez, Mónica, Manzanares, Angela, Cano, Olga, Alonso, Roberto, Sepúlveda‐Crespo, Daniel, Tarancón‐Díez, Laura, Muñoz‐Fernández, María Ángeles, Muñoz‐Chapuli, Mar, Resino, Salvador, Navarro, Maria Luisa, Martinez, Isidoro
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme 2
Antibodies
antibody
Blood tests
breast milk
Child
Children
cord blood
COVID-19
Female
Humans
Immunization
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Infant, Newborn
Infections
Milk
Mothers
newborn
Newborn babies
Original
Postpartum period
Postpartum women
Pregnancy
Pregnancy Complications, Infectious
pregnant
Prospective Studies
Proteins
SARS-CoV-2
Serum
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
spike glycoprotein
Spike Glycoprotein, Coronavirus
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Summary:Introduction Pregnant women are vulnerable to severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) infection. Neutralizing antibodies against the SARS‐CoV‐2 spike (S) protein protect from severe disease. This study analyzes the antibody titers to SARS‐CoV‐2 S protein in pregnant women and their newborns at delivery, and six months later. Methods We conducted a prospective study on pregnant women with confirmed SARS‐CoV‐2 infection and newborns. Antibody (IgG, IgM, and IgA) titers were determined using immunoassays in serum and milk samples. An angiotensin‐converting enzyme 2 (ACE2) receptor‐binding inhibition assay to the S protein was performed on the same serum and milk samples. Results At birth, antibodies to SARS‐CoV‐2 spike protein were detected in 81.9% of mothers' sera, 78.9% of cord blood samples, and 63.2% of milk samples. Symptomatic women had higher antibody titers (IgG, IgM, and IgA) than the asymptomatic ones (P 
ISSN:0730-7659
1523-536X
1523-536X
DOI:10.1111/birt.12667