Tiotropium as an add‑on treatment to inhaled corticosteroids in children with severe and mild symptomatic asthma: Multi‑center observational study for efficacy and safety analysis

Children aged 6-11 years with uncontrolled asthma are treated with low-dose inhaled corticosteroid (ICS) with stepwise increase in ICS dosage and/or add-on maintenance treatment, as necessary. The objective of the present study was to evaluate the efficacy and safety of tiotropium add-on treatment i...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2022-09, Vol.24 (3), Article 577
Main Authors: Aierken, Aibibai, Fu, Bu Wei Mai Erye Mu Yu Su, Xu, Peiru
Format: Article
Language:English
Subjects:
Asthma
Asthma in children
Chronic illnesses
Corticosteroids
Dosage and administration
Drug therapy
Drug therapy, Combination
Immunomodulators
Observational studies
Pediatric research
Pediatrics
Respiratory system
Statistical analysis
Steroids
Testing
Tiotropium
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Summary:Children aged 6-11 years with uncontrolled asthma are treated with low-dose inhaled corticosteroid (ICS) with stepwise increase in ICS dosage and/or add-on maintenance treatment, as necessary. The objective of the present study was to evaluate the efficacy and safety of tiotropium add-on treatment in children with severe and mild symptomatic asthma. The present prospective cohort study included 144 children with severe and mild asthma (age, 6-11 years) who received ICS (budesonide) with [greater than or equal to] 1 controller treatment combination therapies for [greater than or equal to] 1 month and score [greater than or equal to] 1.5 based on Asthma Control Questionnaire-Interviewer-Administered. In addition to ICS with [greater than or equal to] 1 controller treatment, children received 5 [micro]g once-daily tiotropium (treatment group; n=72) or did not receive tiotropium (control group; n=72). The peak forced expiratory volume in 1-sec change from the baseline 3 h post-administration of tiotropium was significantly improved in the treatment group compared with the control group (384 [+ or -] 31 vs. 248 [+ or -] 28 ml; P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2022.11514