Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

The transformation of normal to malignant cells is accompanied by substantial changes in gene expression programs through diverse mechanisms. Here, we examined the changes in the landscape of transcription start sites and alternative promoter (AP) usage and their impact on the translatome in TCL1-dr...

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Bibliographic Details
Published in:eLife 2022-08, Vol.11
Main Authors: Ogran, Ariel, Havkin-Solomon, Tal, Becker-Herman, Shirly, David, Keren, Shachar, Idit, Dikstein, Rivka
Format: Article
Language:English
Subjects:
alternative promoter
Animals
B cells
Cancer Biology
Carcinogenesis - genetics
Chromosomes and Gene Expression
Chronic lymphocytic leukemia
CLL
DNA binding proteins
Epigenesis, Genetic
Epigenetic inheritance
Genetic engineering
Genetic translation
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Mice
Mice, Transgenic
Polyribosomes - metabolism
polysome-CAGE
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
RNA
TCL1
transcription start site
translation
Citations: Items that this one cites
Online Access:Get full text
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