Clinical opportunity awaits at the intersection of genomics and brain imaging

It is well known in neuroimaging studies that different brain atlases, or the way different regions of interest are defined, can have a significant impact on findings. This methodological choice is equally important for genomic studies integrating brain imaging data. Many previous cortical genome-wi...

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Bibliographic Details
Published in:Journal of psychiatry & neuroscience 2022-07, Vol.47 (4), p.E293-E298
Main Authors: Makowski, Carolina, Wang, Hao, Chen, Chi-Hua
Format: Article
Language:English
Subjects:
Autism
Brain
Brain mapping
Disease
Forecasts and trends
Gene expression
Gene loci
Genetic diversity
Genome-wide association studies
Genomics
Magnetic resonance imaging
Medical imaging
Mental disorders
Morphology
Mutation
Neuroimaging
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Summary:It is well known in neuroimaging studies that different brain atlases, or the way different regions of interest are defined, can have a significant impact on findings. This methodological choice is equally important for genomic studies integrating brain imaging data. Many previous cortical genome-wide association studies have been successful in identifying novel genetic variants underlying morphological features of the brain, but typically define brain regions based on anatomical patterns. Here, Makowski examines genetic information to draw regional brain boundaries, potentially improving discovery of genetic loci linked to the cortex compared with previous studies.
ISSN:1180-4882
1488-2434
DOI:10.1503/jpn.220075