Validation and Application of MD Anderson Symptom Inventory Module for Patients with Bladder Cancer in the Perioperative Setting

Objectives: We developed and validated a disease-specific tool for perioperative patient-reported outcomes assessment for bladder cancer (BLC) patients undergoing radical cystectomy, The MD Anderson Symptom Inventory (the MDASI-PeriOp-BLC). Methods: Patients who underwent radical cystectomy were rec...

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Bibliographic Details
Published in:Cancers 2022-08, Vol.14 (16), p.3896
Main Authors: Kamal, Mona, Navai, Neema, Bree, Kelly K, Williams, Loretta A, Cleeland, Charles S, Shen, Shu-En, Wang, Xin Shelley
Format: Article
Language:English
Subjects:
Activities of daily living
Bladder cancer
Burning
Cancer
Care and treatment
Clinical trials
Cognitive ability
Comorbidity
Constipation
Diagnosis
Health aspects
Interviews
Metastasis
Methods
Ostomy
Patient compliance
Patient satisfaction
Patient-centered care
Patients
Preoperative care
Quality of life
Recovery (Medical)
Recovery of function
Surgery
Surgical outcomes
Urination
Validation studies
Validity
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Summary:Objectives: We developed and validated a disease-specific tool for perioperative patient-reported outcomes assessment for bladder cancer (BLC) patients undergoing radical cystectomy, The MD Anderson Symptom Inventory (the MDASI-PeriOp-BLC). Methods: Patients who underwent radical cystectomy were recruited. We used qualitative interviews and experts’ input to generate disease/treatment-specific items of the MDASI-PeriOp-BLC module; conducted item reduction; examined the psychometric properties of the resultant items for reliability, validity, and clinical interpretability; and conducted cognitive debriefing interviews to assess the tool’s performance. Results: A total of 150 BLC patients contributed to psychometric validation. We identified and defined eight BLC-specific module items (blood in urine, leaking urine, frequent urination, urinary urgency, burning with urination, constipation, changes in sexual function, and stomal problems). We included those 8 items in addition to 13 MDASI core symptoms and 6 interference items to form the MDASI-PeriOp-BLC module. Cronbach alphas were 0.89 and 0.90 for the 21 severity items and the 6 interference items, respectively. Test−retest reliability (intra-class correlation) was 0.92 for the 21 severity items. The MDASI-PeriOp-BLC module significantly differentiated the patients by performance status (p < 0.0001). Conclusions: The MDASI-PeriOp-BLC is a valid, reliable, and concise tool for monitoring symptom burden during perioperative care in BLC patients undergoing radical cystectomy.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14163896