In Vitro and In Vivo Investigation on the Effectiveness of Alginate-Based Gastric Mucosal Protective Gel

Objective. To investigate the feasibility and effectiveness of an alginate-based gastric mucosal protective gel on the gastric ulcer. Methods. (1) In the physical protection model, after GES-1 cell attachment add the gel to transwell chamber, add different concentrations of HCl to the gel. Absorbanc...

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Published in:BioMed research international 2022-08, Vol.2022, p.1-11
Main Authors: Zeng, Hang, He, Muye, Yang, Minyi, Meng, Zhu, Wang, Han, Wang, Chunren
Format: Article
Language:English
Subjects:
Alginates
Alginic acid
Cell adhesion
Cell proliferation
Connective tissues
Effectiveness
Endoscopy
Gastric cancer
Gastric juice
Gastric mucosa
Gels (Pharmacy)
Health aspects
Histology
Hydrochloric acid
Hyperplasia
In vivo methods and tests
Infiltration
Inflammation
Laboratory animals
Leukocyte migration
Lymphocytes
Muscles
Necrosis
Prevention
Stomach ulcer
Ulcers
Wound healing
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creator Zeng, Hang
He, Muye
Yang, Minyi
Meng, Zhu
Wang, Han
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description Objective. To investigate the feasibility and effectiveness of an alginate-based gastric mucosal protective gel on the gastric ulcer. Methods. (1) In the physical protection model, after GES-1 cell attachment add the gel to transwell chamber, add different concentrations of HCl to the gel. Absorbance was measured to assess proliferation and images of the cells migrating into the wound were taken; then the migration rate of the cells was quantified by comparing images. (2) In the gastric ulcer model, excise the gastric mucosal of SD rats; the gel and fixative were applied on the artificial ulcer immediately. Dissect rats after 10 days, and calculate the wound healing rate and analyzed histology changes. Results. The effect of hydrochloric acid on cells in the lower layer was significantly reduced after the use of gastric mucosal protection gel. The protective gel had an isolation effect on different concentrations of acid. A number of GES-1 were significantly higher than those in the control group at 24 h to 72 h (P
doi_str_mv 10.1155/2022/8287163
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To investigate the feasibility and effectiveness of an alginate-based gastric mucosal protective gel on the gastric ulcer. Methods. (1) In the physical protection model, after GES-1 cell attachment add the gel to transwell chamber, add different concentrations of HCl to the gel. Absorbance was measured to assess proliferation and images of the cells migrating into the wound were taken; then the migration rate of the cells was quantified by comparing images. (2) In the gastric ulcer model, excise the gastric mucosal of SD rats; the gel and fixative were applied on the artificial ulcer immediately. Dissect rats after 10 days, and calculate the wound healing rate and analyzed histology changes. Results. The effect of hydrochloric acid on cells in the lower layer was significantly reduced after the use of gastric mucosal protection gel. The protective gel had an isolation effect on different concentrations of acid. A number of GES-1 were significantly higher than those in the control group at 24 h to 72 h (P&lt;0.01). The migration was observed compared with the control group. The average healing rate of ulcer in the gel group was about 50%, and the control group was about 30%. Inflammation occurred in all wound regions after ten days. In the gel group, inflammatory infiltration depth was lower than that of the control, and part of SD rats’ new muscle layer appeared without inflammatory infiltration. The connective tissue proliferation promoted tissue repair. In the control group, necrosis marginal, mucosal hyperplasia, marginal lymphocyte aggregation, and bleeding were observed. Conclusion. This novel gel mainly has an isolating and shielding effect to prevent the wound from being exposed to gastric acid for a long time, and it can reduce the inflammatory reaction on the wounds to promote the healing of the ulcer. The gastric mucosal protective gel cannot only promote the speed of wound healing but also improve the quality of wound healing.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/8287163</identifier><identifier>PMID: 36060134</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Alginates ; Alginic acid ; Cell adhesion ; Cell proliferation ; Connective tissues ; Effectiveness ; Endoscopy ; Gastric cancer ; Gastric juice ; Gastric mucosa ; Gels (Pharmacy) ; Health aspects ; Histology ; Hydrochloric acid ; Hyperplasia ; In vivo methods and tests ; Infiltration ; Inflammation ; Laboratory animals ; Leukocyte migration ; Lymphocytes ; Muscles ; Necrosis ; Prevention ; Stomach ulcer ; Ulcers ; Wound healing</subject><ispartof>BioMed research international, 2022-08, Vol.2022, p.1-11</ispartof><rights>Copyright © 2022 Hang Zeng et al.</rights><rights>COPYRIGHT 2022 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2022 Hang Zeng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Hang Zeng et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-222710115364270bd792e3a23bd325cec2182b76c53852d137e6056e8f0058503</citedby><cites>FETCH-LOGICAL-c453t-222710115364270bd792e3a23bd325cec2182b76c53852d137e6056e8f0058503</cites><orcidid>0000-0002-6699-9385 ; 0000-0001-5102-2400 ; 0000-0001-5497-1986</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2709598020/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2709598020?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids></links><search><contributor>Chiba, Toshimi</contributor><contributor>Toshimi Chiba</contributor><creatorcontrib>Zeng, Hang</creatorcontrib><creatorcontrib>He, Muye</creatorcontrib><creatorcontrib>Yang, Minyi</creatorcontrib><creatorcontrib>Meng, Zhu</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Wang, Chunren</creatorcontrib><title>In Vitro and In Vivo Investigation on the Effectiveness of Alginate-Based Gastric Mucosal Protective Gel</title><title>BioMed research international</title><description>Objective. To investigate the feasibility and effectiveness of an alginate-based gastric mucosal protective gel on the gastric ulcer. Methods. (1) In the physical protection model, after GES-1 cell attachment add the gel to transwell chamber, add different concentrations of HCl to the gel. Absorbance was measured to assess proliferation and images of the cells migrating into the wound were taken; then the migration rate of the cells was quantified by comparing images. (2) In the gastric ulcer model, excise the gastric mucosal of SD rats; the gel and fixative were applied on the artificial ulcer immediately. Dissect rats after 10 days, and calculate the wound healing rate and analyzed histology changes. Results. The effect of hydrochloric acid on cells in the lower layer was significantly reduced after the use of gastric mucosal protection gel. The protective gel had an isolation effect on different concentrations of acid. A number of GES-1 were significantly higher than those in the control group at 24 h to 72 h (P&lt;0.01). The migration was observed compared with the control group. The average healing rate of ulcer in the gel group was about 50%, and the control group was about 30%. Inflammation occurred in all wound regions after ten days. In the gel group, inflammatory infiltration depth was lower than that of the control, and part of SD rats’ new muscle layer appeared without inflammatory infiltration. The connective tissue proliferation promoted tissue repair. In the control group, necrosis marginal, mucosal hyperplasia, marginal lymphocyte aggregation, and bleeding were observed. Conclusion. This novel gel mainly has an isolating and shielding effect to prevent the wound from being exposed to gastric acid for a long time, and it can reduce the inflammatory reaction on the wounds to promote the healing of the ulcer. The gastric mucosal protective gel cannot only promote the speed of wound healing but also improve the quality of wound healing.</description><subject>Alginates</subject><subject>Alginic acid</subject><subject>Cell adhesion</subject><subject>Cell proliferation</subject><subject>Connective tissues</subject><subject>Effectiveness</subject><subject>Endoscopy</subject><subject>Gastric cancer</subject><subject>Gastric juice</subject><subject>Gastric mucosa</subject><subject>Gels (Pharmacy)</subject><subject>Health aspects</subject><subject>Histology</subject><subject>Hydrochloric acid</subject><subject>Hyperplasia</subject><subject>In vivo methods and tests</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Leukocyte migration</subject><subject>Lymphocytes</subject><subject>Muscles</subject><subject>Necrosis</subject><subject>Prevention</subject><subject>Stomach ulcer</subject><subject>Ulcers</subject><subject>Wound healing</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kVFvFCEQx4nR2Kb2zQ9A4ouJrgVmYdkXk2tTzyY1-qC-Eo6dvaPZgwrsGb-9XO9Sow9OSAYyP_7M8CfkJWfvOJfyQjAhLrTQHVfwhJwK4G2jeMufPu4BTsh5zneshuaK9eo5OQHFFOPQnpLNTaDffUmR2jDQh8Mu1rzDXPzaFh8DratskF6PI7ridxgwZxpHupjWPtiCzaXNONClzSV5Rz_NLmY70S8plsMFusTpBXk22inj-TGfkW8frr9efWxuPy9vrha3jWsllEYI0XFWZwPVio6thq4XCFbAagAhHTrBtVh1yknQUgwcOlRMKtQjY1JLBmfk_UH3fl5tcXAYSrKTuU9-a9MvE603f1eC35h13Jm-BRBKVYHXR4EUf8z1G8zWZ4fTZAPGOZvaVd9zkFJW9NU_6F2cU6jjPVCy10ywP9TaTmh8GGN91-1FzaL6xltdBSv19kC5FHNOOD62zJnZe232Xpuj1xV_c8A3Pgz2p_8__RugtKPY</recordid><startdate>20220824</startdate><enddate>20220824</enddate><creator>Zeng, Hang</creator><creator>He, Muye</creator><creator>Yang, Minyi</creator><creator>Meng, Zhu</creator><creator>Wang, Han</creator><creator>Wang, Chunren</creator><general>Hindawi</general><general>John Wiley &amp; 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To investigate the feasibility and effectiveness of an alginate-based gastric mucosal protective gel on the gastric ulcer. Methods. (1) In the physical protection model, after GES-1 cell attachment add the gel to transwell chamber, add different concentrations of HCl to the gel. Absorbance was measured to assess proliferation and images of the cells migrating into the wound were taken; then the migration rate of the cells was quantified by comparing images. (2) In the gastric ulcer model, excise the gastric mucosal of SD rats; the gel and fixative were applied on the artificial ulcer immediately. Dissect rats after 10 days, and calculate the wound healing rate and analyzed histology changes. Results. The effect of hydrochloric acid on cells in the lower layer was significantly reduced after the use of gastric mucosal protection gel. The protective gel had an isolation effect on different concentrations of acid. A number of GES-1 were significantly higher than those in the control group at 24 h to 72 h (P&lt;0.01). The migration was observed compared with the control group. The average healing rate of ulcer in the gel group was about 50%, and the control group was about 30%. Inflammation occurred in all wound regions after ten days. In the gel group, inflammatory infiltration depth was lower than that of the control, and part of SD rats’ new muscle layer appeared without inflammatory infiltration. The connective tissue proliferation promoted tissue repair. In the control group, necrosis marginal, mucosal hyperplasia, marginal lymphocyte aggregation, and bleeding were observed. Conclusion. This novel gel mainly has an isolating and shielding effect to prevent the wound from being exposed to gastric acid for a long time, and it can reduce the inflammatory reaction on the wounds to promote the healing of the ulcer. The gastric mucosal protective gel cannot only promote the speed of wound healing but also improve the quality of wound healing.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>36060134</pmid><doi>10.1155/2022/8287163</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6699-9385</orcidid><orcidid>https://orcid.org/0000-0001-5102-2400</orcidid><orcidid>https://orcid.org/0000-0001-5497-1986</orcidid><oa>free_for_read</oa></addata></record>
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subjects Alginates
Alginic acid
Cell adhesion
Cell proliferation
Connective tissues
Effectiveness
Endoscopy
Gastric cancer
Gastric juice
Gastric mucosa
Gels (Pharmacy)
Health aspects
Histology
Hydrochloric acid
Hyperplasia
In vivo methods and tests
Infiltration
Inflammation
Laboratory animals
Leukocyte migration
Lymphocytes
Muscles
Necrosis
Prevention
Stomach ulcer
Ulcers
Wound healing
title In Vitro and In Vivo Investigation on the Effectiveness of Alginate-Based Gastric Mucosal Protective Gel
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