Haart impact on prevalence of chronic otitis media in Brazilian HIV-infected children

The advent of new antiretroviral drugs such as protease inhibitors has generated sensible changes in morbity and mortality in HIV-infected patients. To evaluate the impact of Highly Active Antiretroviral Therapy (HAART) on the prevalence of chronic otitis media in HIV-infected pediatric population....

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2006-07, Vol.72 (4), p.509-514
Main Authors: Weber, Raimar, Neto, Carlos Diógenes Pinheiro, Miziara, Ivan Dieb, Filho, Bernardo Cunha Araújo
Format: Article
Language:English
Subjects:
Age Factors
Anti-HIV Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Brazil - epidemiology
CD4 Lymphocyte Count
Child
Child, Preschool
Chronic Disease
chronic otitis media
Female
haart
hiv infections
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
Humans
Infant
Infant, Newborn
Male
Original
Otitis Media - epidemiology
Otitis Media - etiology
Otitis Media - immunology
Prevalence
Retrospective Studies
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Summary:The advent of new antiretroviral drugs such as protease inhibitors has generated sensible changes in morbity and mortality in HIV-infected patients. To evaluate the impact of Highly Active Antiretroviral Therapy (HAART) on the prevalence of chronic otitis media in HIV-infected pediatric population. We analyzed medical charts of 471 children aged zero to 12 years and 11 months with HIV infection from an Ambulatory of ENT and AIDS. Children were divided according to the age: 0 to 5 years and 11 months and 6 to 12 years and 11 months and classified as having chronic otitis media based on history, physical examination, audiologic and tympanometric data. Prevalence of chronic otitis media, as well as CD4+ lymphocyte count were compared between groups in use of HAART and the group without HAART. Out of 459 children, 65 (14.2%) had chronic otitis media. We observed that in children aged 0 to 5 years and 11 months who were taking HAART there was significant lower prevalence of chronic otitis media (p = 0.02). The use of HAART was associated to higher mean CD4+ lymphocyte count (p < 0.001). The use of HAART was associated to reduction in prevalence of chronic otitis media in HIV infected children, probably due to increase in mean CD4+ lymphocyte count.
ISSN:1808-8694
1808-8686
DOI:10.1016/S1808-8694(15)30997-6