Active Observation of Biochemical Recurrence without Treatment following Radical Prostatectomy: Long-Term Analysis of Outcomes

Biochemical recurrence (BCR) following radical prostatectomy (RP) is an unreliable predictor of prostate cancer (PC) progression. This study was a retrospective cohort analysis of prospectively collected data (407/1895) of men with BCR at a tertiary referral center. Patients were assessed for active...

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Bibliographic Details
Published in:Cancers 2022-08, Vol.14 (17), p.4078
Main Authors: Huang, Erica, Huynh, Linda My, Tran, Joshua, Gordon, Adam M, Chandhoke, Ryan, Morales, Blanca, Skarecky, Douglas, Ahlering, Thomas E
Format: Article
Language:English
Subjects:
Cancer therapies
Care and treatment
Cell division
Demographics
Health aspects
Intervention
Metastasis
Mortality
Patient outcomes
Patients
Prostate cancer
Prostate-specific antigen
Prostatectomy
Risk assessment
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Summary:Biochemical recurrence (BCR) following radical prostatectomy (RP) is an unreliable predictor of prostate cancer (PC) progression. This study was a retrospective cohort analysis of prospectively collected data (407/1895) of men with BCR at a tertiary referral center. Patients were assessed for active observation (AO) compared with a treatment group (TG) utilizing doubling time (DT) kinetics. Risk assessment was based on the initial DT (>12 vs. 12 months in 73.6% of AO versus 22.6% of TG (p < 0.001). An increasing DT pattern was observed in 71.5% of AO versus 32.7% of TG (p < 0.001). Utilizing the Cleveland Clinic’s PCSM nomogram, at 10 years, predicted and observed PCSM was 8.6% and 9.5% (p = 0.78), respectively. In conclusion, one-third of patients with BCR post-RP were managed without treatment using DT kinetics, avoiding treatment-related complications, quality-of-life issues, and expenses.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14174078