New Perspectives on Micronised Purified Flavonoid Fraction in Chronic Venous Disease: From Microvalves to Clinical Effectiveness

The importance of chronic venous disease (CVD), as a cause of reduced quality of life and increased costs to healthcare systems, is expected to rise in parallel with population aging and the increasing prevalence of obesity. Venoactive drugs (VADs) are frequently used to treat the symptoms and signs...

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Bibliographic Details
Published in:Advances in therapy 2022-10, Vol.39 (10), p.4413-4422
Main Authors: Bouskela, Eliete, Lugli, Marzia, Nicolaides, Andrew
Format: Article
Language:English
Subjects:
Animals
Cardiology
Chronic Disease
Edema
Endocrinology
Flavonoids - pharmacology
Flavonoids - therapeutic use
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Pharmacology/Toxicology
Quality of Life
Review
Rheumatology
Treatment Outcome
Vascular Diseases - drug therapy
Venous Insufficiency - complications
Venous Insufficiency - diagnosis
Venous Insufficiency - drug therapy
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Summary:The importance of chronic venous disease (CVD), as a cause of reduced quality of life and increased costs to healthcare systems, is expected to rise in parallel with population aging and the increasing prevalence of obesity. Venoactive drugs (VADs) are frequently used to treat the symptoms and signs of CVD. The most commonly used and widely studied VAD, micronised purified flavonoid fraction (MPFF), is effective at all stages of CVD, and has been shown to significantly reduce leg pain, leg heaviness and swelling, as well as ankle oedema and functional discomfort, in clinical trials. Recently, experiments employing animal models of CVD have demonstrated that MPFF has anti-inflammatory and venotonic effects at the microvalve level, and a pilot clinical study in patients with CVD has provided support for these findings. Collectively, these results suggest that early initiation of MPFF treatment may have the potential to favourably alter the clinical course of the disease, although further clinical data are required to confirm these findings. International guidelines on CVD management strongly recommend MPFF to reduce symptoms and improve quality of life. Studies are now needed to investigate the impact of long-term treatment on disease progression.
ISSN:0741-238X
1865-8652
DOI:10.1007/s12325-022-02218-x