People living with HIV have low trabecular bone mineral density, high bone marrow adiposity, and poor trabecular bone microarchitecture at the proximal femur

• Published in: Osteoporosis international 2022-08, Vol.33 (8), p.1739-1753
• Main Authors: Carballido-Gamio, J., Posadzy, M., Wu, P.-H., Kenny, K., Saeed, I., Link, T. M., Tien, P. C., Krug, R., Kazakia, G. J.
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon - methods; Adipose tissue; Adiposity; Body composition; Bone Density; Bone imaging; Bone Marrow; Bone mineral density; Bone strength; Cancellous bone; Cancellous Bone - diagnostic imaging; Computed tomography; Cortical bone; Endocrinology; Femur; Femur - diagnostic imaging; Fractures; Hip; HIV; Human immunodeficiency virus; Humans; Magnetic resonance imaging; Medicine; Medicine & Public Health; Original Article; Orthopedics; Osteoporosis; Osteoporosis - etiology; Rheumatology; Tomography; Trochanter
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-022-06405-y

Summary People living with HIV (PLWH) have increased risk of osteoporosis and fractures. We assessed the proximal femur of PLWH and age-matched seronegative controls using quantitative computed tomography and magnetic resonance imaging. Results suggest that the trabecular compartment is compromised at fracture-prone regions in the proximal femur of PLWH. Introduction People living with HIV (PLWH) have increased risk of osteoporosis and fractures. However, studies assessing the main determinants of bone strength in the proximal femur exclude this vulnerable population. We assessed the proximal femur of 40 PLWH and 26 age-matched seronegative controls using quantitative computed tomography and magnetic resonance imaging. Methods We examined cortical volumetric bone mineral density (Ct.vBMD), trabecular vBMD (Tb.vBMD), cortical thickness (Ct.Th), bone marrow adiposity (BMA), and trabecular number, separation, and bone volume fraction. Parametric comparisons between the two groups were made for the femoral head, femoral neck, trochanter, and total hip using linear regression adjusting for several covariates, including metrics of body composition. In addition, we investigated the associations of BMA with Tb.vBMD and trabecular microarchitecture with Spearman’s rank partial correlations. Results PLWH had lower Tb.vBMD and deteriorated trabecular microarchitecture in the femoral neck, trochanter and total hip, and elevated BMA in the femoral head, femoral neck, and total hip. Ct.vBMD and Ct.Th were not significantly different between the two groups. BMA was significantly associated with lower Tb.vBMD and deteriorated trabecular microarchitecture in both groups albeit at different femoral regions. Conclusions Our findings suggest that the trabecular, and not the cortical, compartment is compromised in the proximal femur of PLWH. The observed impairments in fracture-prone regions in PLWH indicate lower femoral strength and suggest higher fracture risk. The inverse associations of BMA with trabecular bone density and microarchitecture quality agree with findings at other anatomic sites and in other populations, suggesting that excess BMA possibly due to a switch from the osteoblast to the adipocyte lineage may be implicated in the pathogenesis of bone fragility at the femur in PLWH.