Neuroblastoma: When differentiation goes awry

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2022-09, Vol.110 (18), p.2916-2928
Main Authors: Zeineldin, Maged, Patel, Anand G., Dyer, Michael A.
Format: Article
Language:English
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Summary:Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease. This review by Zeinelden et al. discusses the origin of neuroblastoma from the developing sympathoadrenal lineage. The authors argue that neuroblastoma is a disease of arrested differentiation and describe how tumor cell heterogeneity reflects underlying developmental mechanisms.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2022.07.012