COVID‐19 vaccine humoral response in frequent platelet donors with plateletpheresis‐associated lymphopenia

Background Plateletpheresis involves platelet separation and collection from whole blood while other blood cells are returned to the donor. Because platelets are replaced faster than red blood cells, as many as 24 donations can be done annually. However, some frequent apheresis platelet donors (>...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2022-09, Vol.62 (9), p.1779-1790
Main Authors: Laumaea, Annemarie Eare, Lewin, Antoine, Chatterjee, Debashree, Marchitto, Lorie, Ding, Shilei, Gendron‐Lepage, Gabrielle, Goyette, Guillaume, Allard, Marie‐Ève, Simard, Carl, Tremblay, Tony, Perreault, Josée, Duerr, Ralf, Finzi, Andrés, Bazin, Renée
Format: Article
Language:English
Subjects:
Antibodies
Apheresis
Binding
Blood Donors
Blood Donors and Blood Collection
Blood platelets
CD4 antigen
COVID-19
COVID-19 - prevention & control
COVID-19 - therapy
COVID-19 vaccines
COVID-19 Vaccines - adverse effects
Cytotoxicity
donor health
Erythrocytes
Humans
humoral responses
Immune response (humoral)
Immunization
Immunoglobulin G
Lymphocytes
Lymphocytes T
Lymphopenia
Lymphopenia - etiology
Neutralization
Platelet Count
plateletpheresis
Plateletpheresis - methods
Platelets
Toxicity
Vaccination
Vaccines
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Summary:Background Plateletpheresis involves platelet separation and collection from whole blood while other blood cells are returned to the donor. Because platelets are replaced faster than red blood cells, as many as 24 donations can be done annually. However, some frequent apheresis platelet donors (>20 donations annually) display severe plateletpheresis‐associated lymphopenia; in particular, CD4+T but not B cell numbers are decreased. COVID‐19 vaccination thereby provides a model to assess whether lymphopenic platelet donors present compromised humoral immune responses. Study Design and Methods We assessed vaccine responses following 2 doses of COVID‐19 vaccination in a cohort of 43 plateletpheresis donors with a range of pre‐vaccination CD4+T cell counts (76–1537 cells/μl). In addition to baseline T cell measurements, antibody binding assays to full‐length Spike and the Receptor Binding Domain (RBD) were performed pre‐ and post‐vaccination. Furthermore, pseudo‐particle neutralization and antibody‐dependent cellular cytotoxicity assays were conducted to measure antibody functionality. Results Participants were stratified into two groups:
ISSN:0041-1132
1537-2995
1537-2995
DOI:10.1111/trf.17037