Unusual presentation of Ewing sarcoma; a case report and literature review

• Published in: International journal of surgery case reports 2022-10, Vol.99, p.107479, Article 107479
• Main Authors: Al-Marshad, Abdullah Y., AlMazrua, Ibrahim S., AlMulla, Farah, Alaboud, Mohammed, Alrifaie, Omar, Shaheen, Mahmoud, Rajeev, Pant
• Format: Article
• Language: English
• Subjects: Atypical; Case Report; Ewing; Sarcoma
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2022.107479

Introduction and importance Ewing's sarcoma is an aggressive malignancy primarily affecting skeletal system in children and young adults. We report an unusual case of Ewing sarcoma in a 14-year-old boy with clinical and radiological features of rapid onset metachronous skeletal metastasis (within 4 weeks of diagnosis). Although the deterioration of symptoms was very rapid, it is unusual to note that in the presence of such widespread metastatic disease the lungs per se remained uninvolved. We describe a unique case of metastatic Ewing's sarcoma who showed rapid systemic disease progression with widespread skeletal metastases (and CNS involvement) but without any evidence of pulmonary involvement. •Ewing sarcoma is considered aggressive malignancy primarily affecting skeletal system.•It is usually very slowly progressive in nature (years).•This case presentation showed aggressiveness behavior with very unpredictable outcomes short period from diagnosis to metastasis.•Up to our knowledge, this atypical and rapid disease progression (within a month of diagnosis) was not previously reported in literature.