Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese

Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune syst...

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Bibliographic Details
Published in:Genes 2022-10, Vol.13 (10), p.1884
Main Authors: Nhung, Vu Phuong, Ton, Nguyen Dang, Ngoc, Tran Thi Bich, Thuong, Ma Thi Huyen, Hai, Nguyen Thi Thanh, Oanh, Kim Thi Phuong, Hien, Le Thi Thu, Thach, Pham Ngoc, Hai, Nong Van, Ha, Nguyen Hai
Format: Article
Language:English
Subjects:
ABO system
Alleles
Asian People
Asymptomatic
Blood groups
Chromosomes
Coronaviruses
COVID-19
COVID-19 - genetics
Disease susceptibility
Disease transmission
Genes
Genetic aspects
Genetic diversity
Genomes
Genotypes
Health risk assessment
Humans
Immune system
Infections
Membrane Transport Proteins
Mortality
Pandemics
Population studies
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Tyk2 protein
Vietnam - epidemiology
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Summary:Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for the association of host genetic variants with COVID-19, but the data are mostly acquired from Europe. In the current work, we explored the link between host genes (SARS-CoV-2 entry and immune system related to COVID-19 sensitivity/severity) and ABO blood types with COVID-19 from whole-exome data of 200 COVID-19 patients and 100 controls in Vietnam. The O blood type was found to be a protective factor that weakens the worst outcomes of infected individuals. For SARS-CoV-2 susceptibility, rs2229207 (TC genotype, allele C) and rs17860118 (allele T) of increased the risk of infection, but rs139940581 (CT genotype, allele T) of reduced virus sensitivity. For COVID-19 progress, the frequencies of rs4622692 (TG genotype) and rs1048610 (TC genotype) of were significantly higher in the moderate group than in the severe/fatal group. The variant rs12329760 (AA genotype) of was significantly associated with asymptomatic/mild symptoms. Additionally, rs2304255 (CT genotype, allele T) of and rs2277735 (AG genotype) of were associated with severe/fatal outcomes. Studies on different populations will give better insights into the pathogenesis, which is ethnic-dependent, and thus decipher the genetic factor's contribution to mechanisms that predispose people to being more vulnerable to COVID-19.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13101884