Marijuana use and DNA methylation-based biological age in young adults

Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana's effect on aging remains understudied and understanding the effects of marijuana on molecular aging may provide novel insigh...

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Bibliographic Details
Published in:Clinical epigenetics 2022-10, Vol.14 (1), p.134, Article 134
Main Authors: Nannini, Drew R, Zheng, Yinan, Joyce, Brian T, Gao, Tao, Liu, Lei, Jacobs, Jr, David R, Schreiner, Pamela, Liu, Chunyu, Horvath, Steve, Lu, Ake T, Yaffe, Kristine, Sidney, Stephen, Greenland, Philip, Lloyd-Jones, Donald M, Hou, Lifang
Format: Article
Language:English
Subjects:
Age
Aging
Aging - genetics
Alcohol
Alcohol use
Biomarkers
Blood
Cannabis
Cardiovascular disease
Coronary artery
DNA
DNA Methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenomics - methods
Estimates
Humans
Life span
Marijuana
Marijuana Use - genetics
Methylation
Quality control
Regression analysis
Smoking
Teenagers
Tobacco
Variables
Young Adult
Young adults
Youth
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Summary:Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana's effect on aging remains understudied and understanding the effects of marijuana on molecular aging may provide novel insights into the role of marijuana in the aging process. We therefore sought to investigate the association between cumulative and recent use of marijuana with epigenetic age acceleration (EAA) as estimated from blood DNA methylation. A random subset of participants from The Coronary Artery Risk Development in Young Adults (CARDIA) Study with available whole blood at examination years (Y) 15 and Y20 underwent epigenomic profiling. Four EAA estimates (intrinsic epigenetic age acceleration, extrinsic epigenetic age acceleration, PhenoAge acceleration, and GrimAge acceleration) were calculated from DNA methylation levels measured at Y15 and Y20. Ever use and cumulative marijuana-years were calculated from the baseline visit to Y15 and Y20, and recent marijuana use (both any and number of days of use in the last 30 days) were calculated at Y15 and Y20. Ever use of marijuana and each additional marijuana-year were associated with a 6-month (P 
ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-022-01359-8