Computational and comparative investigation of hydrophobic profile of spike protein of SARS-CoV-2 and SARS-CoV

The hydrophobic force is one of the most dominant factors in protein folding. A protein becomes functional only when it achieves its three-dimensional structure and stability upon folding. For a better understanding of the hydrophobic effects and their function in protein folding, quantitative measu...

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Bibliographic Details
Published in:Journal of biological physics 2022-12, Vol.48 (4), p.399-414
Main Authors: Shekhawat, Uma, Roy Chowdhury (Chakravarty), Anindita
Format: Article
Language:English
Subjects:
10. Section - Other (General Biological Physics)
Amino acids
Biochemistry
Biological and Medical Physics
Biophysics
Complex Fluids and Microfluidics
Complex Systems
Computational Biology
Computer applications
Coronaviruses
COVID-19
Humans
Hydrophobic and Hydrophilic Interactions
Hydrophobicity
Investigations
Neurosciences
Pathogenesis
Pathogenicity
Physics
Physics and Astronomy
Protein folding
SARS-CoV-2 - chemistry
Severe acute respiratory syndrome coronavirus 2
Soft and Granular Matter
Spike Glycoprotein, Coronavirus - chemistry
Spike protein
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Summary:The hydrophobic force is one of the most dominant factors in protein folding. A protein becomes functional only when it achieves its three-dimensional structure and stability upon folding. For a better understanding of the hydrophobic effects and their function in protein folding, quantitative measurement of the hydrophobicity of amino acid side chains is crucial. Spike protein is the primary structural protein in SARS-CoV-2 and SARS-CoV. This study explores how protein sequences in SARS-CoV-2 and SARS-CoV spike proteins encode hydrophobic interactions. Computational tools/techniques have been utilized to investigate the protein sequences of the spike proteins of SARS-CoV-2 and SARS-CoV. Investigations provided an estimate of hydrophobic distribution and its relative strength, indicating a hydrophobic pattern. Analysis of the spike protein's hydrophobic profile may help identify and treat the virus-caused disease; additionally, it can give an insight into the transmissibility and pathogenicity of the virus.
ISSN:0092-0606
1573-0689
DOI:10.1007/s10867-022-09615-x