Synovial Fluid pH Sensor for Early Detection of Prosthetic Hip Infections

An implantable sensor developed to measure synovial fluid pH for noninvasive early detection and monitoring of hip infections using standard‐of‐care plain radiography is described. The sensor is made of a pH responsive polyacrylic acid‐based hydrogel, which expands at high pH and contracts at low pH...

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Bibliographic Details
Published in:Advanced functional materials 2021-09, Vol.31 (37), p.n/a
Main Authors: Wijayaratna, Uthpala N., Kiridena, Sachindra D., Adams, John D., Behrend, Caleb J., Anker, Jeffrey N.
Format: Article
Language:English
Subjects:
Electronic implants
hip infections
Hydrogels
Materials science
plain radiographies
Polyacrylic acid
Prostheses
Radiography
Sensors
synovial fluid
Tantalum
Time constant
Wire
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Summary:An implantable sensor developed to measure synovial fluid pH for noninvasive early detection and monitoring of hip infections using standard‐of‐care plain radiography is described. The sensor is made of a pH responsive polyacrylic acid‐based hydrogel, which expands at high pH and contracts at low pH. A radiodense tantalum bead and a tungsten wire are embedded in the two ends of the hydrogel to monitor the change in length of the hydrogel sensor in response to pH via plain radiography. The effective acid dissociation constant (pKa) of the hydrogel‐based pH sensor is 5.6 with a sensitivity of 3 mm/pH unit between pH 4 and 8. The sensor shows a linear response and reversibility in the physiologically relevant pH range of pH 6.5 and 7.5 in both buffer and bovine synovial fluid solutions with a 30‐minute time constant. The sensor is attached to an explanted prosthetic hip, and the pH response is determined from the X‐ray images by measuring the length between the tantalum bead and the radiopaque wire. Therefore, the developed sensor will enable noninvasive detection and studying of implant hip infection using plain radiography. An implantable synovial fluid pH sensor can be attached to a prosthetic hip and noninvasively read via X‐ray imaging for detecting infection. The sensor comprises a pH‐responsive hydrogel with an embedded radiodense tantalum bead. pH controls the degree of hydrogel swelling and thus the radiographically observed bead position. This enables standard postoperative radiographs to quantify local pH.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202104124