Gastrointestinal histopathology of acute colchicine toxicity after lower dose treatment of pericarditis: A case report

Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tissues such as the gastrointestinal tract. These features have o...

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Bibliographic Details
Published in:International Journal of Critical Illness and Injury Science 2022-07, Vol.12 (3), p.174-176
Main Authors: Liu, Lisa, Tessier, Steven, Duarte-Chavez, Rodrigo, Marino, Daniel, Kaza, Anish, Longo, Santo, Nanda, Sudip
Format: Article
Language:English
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Case Report
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Summary:Colchicine is an anti-inflammatory alkaloid drug with anti-microtubule activity. Colchicine toxicity is a serious and potentially fatal complication associated with hallmark histopathological features most conspicuous in proliferative tissues such as the gastrointestinal tract. These features have only been reported in patients treated with high doses. We report a patient who experienced acute colchicine toxicity with gastrointestinal histologic changes after treatment with the lowest dose of colchicine. Knowledge of drug–drug interactions and the organs involved in colchicine metabolism is imperative when using colchicine, even when administered at its lowest dose.
ISSN:2229-5151
2231-5004
DOI:10.4103/ijciis.ijciis_105_21