Analysis of Circulating C19MC MicroRNA as an Early Marker of Hypertension and Preeclampsia in Pregnant Patients: A Systematic Review

Preeclampsia and hypertension complicate several pregnancies. Identifying women at risk of developing these conditions is essential to establish potential treatment modalities. Biomarkers such as C19MC microRNA in pregnant patients wopuld assist in defining pregnancy surveillance and implementing in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2022-11, Vol.11 (23), p.7051
Main Authors: Kondracka, Adrianna, Jaszczuk, Ilona, Koczkodaj, Dorota, Kondracki, Bartosz, Frąszczak, Karolina, Oniszczuk, Anna, Rybak-Krzyszkowska, Magda, Staniczek, Jakub, Filip, Agata, Kwaśniewska, Anna
Format: Article
Language:English
Subjects:
Bias
Clinical medicine
Gene expression
Hypertension
Investigations
Literature reviews
MicroRNAs
Preeclampsia
Pregnancy
Risk assessment
Systematic Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preeclampsia and hypertension complicate several pregnancies. Identifying women at risk of developing these conditions is essential to establish potential treatment modalities. Biomarkers such as C19MC microRNA in pregnant patients wopuld assist in defining pregnancy surveillance and implementing interventions. This study sought to analyze circulating C19MC microRNA as an early marker of hypertension and preeclampsia in pregnant patients. A systematic review was undertaken using the following registers: disease registries, pregnancy registries, and pregnancy exposure registries, and the following databases: PubMed, CINAHL, Web of Science, Scopus, and EMBASE. The risk of bias was assessed using the Cochrane technique. From the 45 publications retrieved from the registers and databases, only 21 were included in the review after the removal of duplicates, screening, and eligibility evaluation. All 210 publications had a low risk of bias and illuminated the potential use of circulating C19MC microRNA as an early marker of hypertension and preeclampsia in pregnant patients. Therefore, it was concluded that C19MC microRNA can be used as an early marker of gestational preeclampsia and hypertension.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11237051