The relationship between temperament, polygenic score for intelligence and cognition: A population‐based study of middle‐aged adults

• Published in: Genes, brain and behavior brain and behavior, 2022-04, Vol.21 (4), p.e12798-n/a
• Main Authors: Tölli, Pekka, Keltikangas‐Järvinen, Liisa, Lehtimäki, Terho, Ravaja, Niklas, Hintsanen, Mirka, Ahola‐Olli, Ari, Pahkala, Katja, Kähönen, Mika, Hutri‐Kähönen, Nina, Laitinen, Tomi T., Tossavainen, Päivi, Taittonen, Leena, Dobewall, Henrik, Jokinen, Eero, Raitakari, Olli, Cloninger, C. Robert, Rovio, Suvi, Saarinen, Aino
• Format: Article
• Language: English
• Subjects: Adult; Attention; CANTAB; Character; Cognition; cognitive abilities; Cognitive ability; cognitive performance; cognitive test; genetic; GWAS; Humans; Information processing; Intelligence; Intelligence - genetics; Memory; Middle age; Middle Aged; Multifactorial Inheritance; Original; polygenic score; Population studies; Population-based studies; prospective; Short term memory; Spatial memory; TCI; Temperament; Visual perception
• ISSN: 1601-1848; 1601-183X; 1601-183X
• DOI: 10.1111/gbb.12798

We investigated whether temperament modifies an association between polygenic intelligence potential and cognitive test performance in midlife. The participants (n = 1647, born between 1962 and 1977) were derived from the Young Finns Study. Temperament was assessed with Temperament and Character Inventory over a 15‐year follow‐up (1997, 2001, 2007, 2012). Polygenic intelligence potential was assessed with a polygenic score for intelligence. Cognitive performance (visual memory, reaction time, sustained attention, spatial working memory) was assessed with CANTAB in midlife. The PGSI was significantly associated with the overall cognitive performance and performance in visual memory, sustained attention and working memory tests but not reaction time test. Temperament did not correlate with polygenic score for intelligence and did not modify an association between the polygenic score and cognitive performance, either. High persistence was associated with higher visual memory (B = 0.092; FDR‐adj. p = 0.007) and low harm avoidance with higher overall cognitive performance, specifically better reaction time (B = −0.102; FDR‐adj; p = 0.007). The subscales of harm avoidance had different associations with cognitive performance: higher “anticipatory worry,” higher “fatigability,” and lower “shyness with strangers” were associated with lower cognitive performance, while the role of “fear of uncertainty” was subtest‐related. In conclusion, temperament does not help or hinder one from realizing their genetic potential for intelligence. The overall modest relationships between temperament and cognitive performance advise caution if utilizing temperament‐related information e.g. in working‐life recruitments. Cognitive abilities may be influenced by temperament variables, such as the drive for achievement and anxiety about test performance, but they involve distinct systems of learning and memory. Temperament traits may be only modestly associated with cognitive performance in midlife. Temperament may not help or hinder one from realizing their genetic potential for intelligence.