Anti-signal Recognition Particle Antibody-positive Immune-mediated Myopathy after mRNA-1273 SARS-CoV-2 Vaccination

A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, an...

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Bibliographic Details
Published in:Internal Medicine 2022/12/01, Vol.61(23), pp.3605-3609
Main Authors: Tanemoto, Masanobu, Oda, Ryosuke, Toyama, Yuichiro, Shizukawa, Hirohiko, Yokokawa, Kazuki, Saito, Taro, Suzuki, Syuuichirou, Matsumura, Akihiro, Hisahara, Shin
Format: Article
Language:English
Subjects:
2019-nCoV Vaccine mRNA-1273
Adult
anti-signal recognition particle antibody
Autoantibodies
Case Report
Coronaviruses
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Creatinine
Female
Fever
Gait
Humans
immune-mediated necrotizing myopathy
Immunotherapy
Internal medicine
Magnetic resonance imaging
Movement disorders
mRNA
Muscles
Muscular Diseases - drug therapy
Muscular Diseases - etiology
Myalgia
Myopathy
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signal Recognition Particle
Tau protein
Vaccination
vaccine
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Summary:A 26-year-old Japanese woman developed a fever, myalgia and gait disturbance one day after receiving the second dose of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. A neurological examination revealed symmetrical weakness and myalgia in proximal lower limbs, and a blood examination showed prominent elevation of creatinine kinase. Magnetic resonance imaging (MRI) revealed a high signal intensity in the thigh muscles on short-tau inversion recovery images, and antibody testing revealed positive findings for anti-signal recognition particle (SRP) antibody. Thus, anti-SRP antibody-positive immune-mediated myopathy was diagnosed. We initiated immunotherapy, and she was ultimately able to walk stably.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0404-22