The temporal association of hyperhidrosis and its comorbidities – a nationwide hospital‐based cohort study

Background Research on hyperhidrosis comorbidities has documented the co‐occurrence of diseases but has not provided information about temporal disease associations. Objective To investigate the temporal disease trajectories of individuals with hospital‐diagnosed hyperhidrosis. Methods This is a hos...

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Published in:Journal of the European Academy of Dermatology and Venereology 2022-12, Vol.36 (12), p.2504-2511
Main Authors: Henning, M.A.S., Reguant, R., Jørgensen, I.F., Andersen, R.K., Ibler, K.S., Pedersen, O.B., Jemec, G.B.E., Brunak, S.
Format: Article
Language:English
Subjects:
Cohort Studies
Comorbidity
Denmark - epidemiology
Female
Hospitals
Humans
Hyperhidrosis - epidemiology
Inpatients
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Original and Short Reports
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Summary:Background Research on hyperhidrosis comorbidities has documented the co‐occurrence of diseases but has not provided information about temporal disease associations. Objective To investigate the temporal disease trajectories of individuals with hospital‐diagnosed hyperhidrosis. Methods This is a hospital‐based nationwide cohort study including all patients with a hospital contact in Denmark between 1994 and 2018. International Classification of Diseases version‐10 diagnoses assigned to inpatients, outpatients and emergency department patients were collected from the Danish National Patient Register. The main outcome was the temporal disease associations occurring in individuals with hyperhidrosis, which was assessed by identifying morbidities significantly associated with hyperhidrosis and then examining whether there was a significant order of these diagnoses using binomial tests. Results Overall, 7 191 519 patients were included. Of these, 8758 (0.12%) patients had localized hyperhidrosis (5674 female sex [64.8%]; median age at first diagnosis 26.9 [interquartile range 21.3–36.1]) and 1102 (0.015%) generalized hyperhidrosis (606 female sex [59.9%]; median age at first diagnosis 40.9 [interquartile range 26.4–60.7]). The disease trajectories comprised pain complaints, stress, epilepsy, respiratory and psychiatric diseases. The most diagnosed morbidities for localized hyperhidrosis were abdominal pain (relative risk [RR] = 121.75; 95% Confidence Interval [CI] 121.14–122.35; P 
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.18351