Archeal tRNA meets biotechnology: From vaccines to genetic code expansion

Engineering new protein functionalities through the addition of noncoded amino acids is a major biotechnological endeavor that needs to overcome the natural firewalls that prevent misincorporation during protein synthesis. This field is in constant evolution driven by the discovery or design of new...

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Bibliographic Details
Published in:The Journal of biological chemistry 2023-01, Vol.299 (1), p.102755-102755, Article 102755
Main Author: Ribas de Pouplana, Lluís
Format: Article
Language:English
Subjects:
Amino Acyl-tRNA Synthetases - metabolism
Archaea
Archaea - genetics
Biotechnology
Editors' Pick Highlight
Genetic Code
Genetic Code expansion
Lysine - metabolism
pyrrolysine
pyrrolysine-tRNA synthetase
RNA, Transfer - genetics
RNA, Transfer - metabolism
tRNA
Vaccines
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Summary:Engineering new protein functionalities through the addition of noncoded amino acids is a major biotechnological endeavor that needs to overcome the natural firewalls that prevent misincorporation during protein synthesis. This field is in constant evolution driven by the discovery or design of new tools, many of which are based on archeal biology. In a recent article published in JBC, one such tool is characterized and its evolution studied, revealing unexpected details regarding the emergence of the universal genetic code machinery.
ISSN:0021-9258
1083-351X
DOI:10.1016/j.jbc.2022.102755